-parameterized family of functions that is designed such that f ( x , y ; θ ) achieves the maximum value for the correct output y . among the various choices for f , if we focus on those that are linear in a combined feature representation of inputs and outputs, ψ ( x , y ),...
This functionality in combination with a long aliphatic chain or a chain carrying an appropriate aromatic system, such as the biphenyl system, and a free carboxyl group leads to highly potent and selective GIVA cPLA2 inhibitors (XI(50) values 0.00007–0.00008) and docking studies aid in ...
viruses Article Protein Binder (ProBi) as a New Class of Structurally Robust Non-Antibody Protein Scaffold for Directed Evolution Phuong Ngoc Pham, Maroš Hulicˇiak, Lada Biedermannová, Jirˇí Cˇ erný , Tatsiana Charnavets, Gustavo Fuertes Šteˇpán Herynek, Lucie Kolárˇová, Petr ...
This last compound was discovered as the best hit of a series of fenamic acid derivatives. It was shown to bind to hTEAD2217–447 (Kd = 28 µM) in two distinct binding sites: the palmitate pocket and the interface 3 region [28]. Its binding affinity to TEAD2 is mainly driven by ...
Hence, we applied ARADD [4] to disentangle the statistics so as to reveal the ARs and ARA Clusters (Patterns) corresponding to their functionality and residing location in the family. We further showed that even the ARAs captured in a Position Weight Matrix (PWM) [6] discovered by the ...