Proteins of the Hsp110 family are molecular chaperones that play important roles in protein homeostasis in eukaryotes. The pathogenic fungus Candida albicans, which causes infections in humans, has a single Hsp110, termed Msi3. Here, we provide proof-of-
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The size, velocity, and heterogeneity of Big Data outclasses conventional data management tools and requires data and metadata to be fully machine-actionable (i.e., eScience-compliant) and thus findable, accessible, interoperable, and reusable (FAIR). Th
The N-terminal methylation required for andalusicin bioactivity, if installed on other lantibiotics, may stimulate their activity and thus can find practical application. Limitations of the study We characterized andalusicin, the first labionin-containing class III lantibiotic from Firmicutes and ...
But if no practical uses can be found for the waste heat from a central power station, e.g., due to distance from potential customers, then moving generation to where the waste heat can find uses may be of great benefit. Even though the efficiency of a small distributed electrical generato...
a class-based TBox and an instance-based ABox approach. The applicability of these two approaches is not limited to phenotypic data but can be used for representing any type of empirical data. The two approaches differ mainly in technical details that have substantial practical consequences in ter...
As well, access to α-GalNAcases that can efficiently cleave α-GalNAc from the A-antigen on red blood cells at pH 7.4 could allow the practical and economic conversion of A-type red blood cells to O-type (14). Whereas several glycosidases that remove A-antigen from RBCs had been discov...
5.2. The Impact of Pdf Estimation and Comparison to Other Methods We use a public data set from UCSB Center for Bio-Image Informatics to demonstrate the impact of PDF estimation method and for comparison with other MI classification methods. The UCSB data set consists of 58 breast tumor histolo...
However, several restrictions to the efficacy of nisin limit its range of practical applications. For instance, nisin has weak inhibition activity against Gram-negative bacteria, and its biological activity is reduced at an elevated pH. Moreover, spontaneous nisin resistance may occur in target ...