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The attachment and removal of clamp proteins that encircle DNA as it is copied and assist its replication and maintenance is mediated by DNA clamp loader and unloader proteins; defects in loading and unloading can increase the rate of damaging mutations. Kyoo-young Lee and Su Hyung Park at the...
The enhancement in speed and processivity that the clamp confers on the polymerase would not be possible without the clamp loader, the less glamorous but much more hardworking handmaiden of the sliding clamp, which diligently loads the clamps onto primed DNA throughout the process of DNA replicatio...
Cascade 50D Fork Clamp 产品说明书 Parts Manual c For Technical Assistance call: 800-227-2233, Fax: 888-329-8207 To Order Parts call: 888-227-2233, Fax: 888-329-0234 OR Write: Cascade Corporation, P.O. Box 20187, Portland, OR 97220 Internet: www.cascorp.com 50D Fork Clamp 50D-CFB-...
Standalone jar support in Jython itself does not currently support.pthfiles and consequentlysite-packages. Clamp works around this by packaging everything inLib/, but this is not desirable due to possible collisions. This means the possibility of subtle changes in class loader resolution, compared ...
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PCNA is loaded on DNA by the clamp loader, which binds, opens, and closes the ring under ATP hydrolysis24. Although the inner surface of the ring is lined with helices containing basic residues that complement the negative charge of the DNA backbone, a tight PCNA–DNA interaction is not ...
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Quantitative in vitro unloading assays24,31 indicate that in the absence of the clamp-loader, a loaded b2-clamp has a long half-life of tunload41 h on the DNA. Although this is decreased by more than an order of magnitude to tunloadB127 s per b2 in the presence of clamp-loader, ...