概述 Print datasheet MSDS ¥3200/100 μL Cat No.CL488-66387 浓度:1000 μg/ml 库存:现货 点击咨询售前客服 点击咨询售后客服 Gene SymbolGSDMD Gene ID (NCBI)79792 RRIDAB_2883325 ConjugateCoraLite® Plus 488 Fluorescent Dye Excitation/Emission Maxima Wavelengths493 nm / 522 nm ...
CL488-20770 targets GSDMD in IF/ICC, FC (Intra) applications and shows reactivity with human, mouse, rat samples. Tested Applications IF/ICC, FC (Intra) Application Description Tested Reactivity human, mouse, rat Immunogen GSDMD fusion protein Ag14757 种属同源性预测 Host / Isotype Rabbit /...
we found the suppression of PIM-1 by SMI-4a could inhibit releasing of LDH and block the cleavage of GSDMD (Fig.3i, j, Additional file1: Fig. S4a, b). Next, we studied how PIM-1 affects the assembly stage of the NLRP3 inflammasome formation. The interaction between NLRP...
It effectively reduced GSDMD-NT production, inhibited caspase-1 activation, and suppressed IL-1β secretion, thereby mitigating NLRP3 inflammasome-induced pyroptosis in J774A.1 cells. These findings suggest that compound 3 warrants further research and development as a promising NLR...
结论:在CIS后,CX3CL1/CX3CR1信号轴可通过小胶质细胞内NF-κBP65/Caspase1/GSDMD信号通路,减少细胞因子IL-1β/IL-18的表达和释放,从而对小胶质细胞激活的神经炎症反应具有重要的调控作用. 展开 关键词: 缺血性脑卒中 卒中后认知功能障碍 神经炎症反应 大脑中动脉栓塞 Morris水迷宫 ...
脂多糖(Lipopolysaccharide, LPS)结合肝细胞表面TLR4,导致含半胱氨酸的天冬氨酸蛋白水解酶11(cysteinyl aspartate specific proteinase-11,caspase-11)的表达增加,并裂解焦孔素(gasderminD,GSDMD),引起内质网内Ca 离子流增加,激活磷酸化钙调素激酶B 使HMGB1 以外泌体的形式释放。
此外,健脾化瘀解毒方含药血清对脂多糖(LPS)诱导的小鼠RAW264.7巨噬细胞的焦亡关键分子NLRP3、GSDMD、Caspase-1具有显著的抑制作用,亦可有效降低巨噬细胞的炎症因子IL-1β、IL-18的表达[39]。李保良等[40]的临床研究结果显示,健脾化痰法(以参苓白术散合二陈汤为主方加减)可通过降低脾虚型慢性脾胃病患者(主要包括...
焦亡的信号分子gasdermin D(GSDMD-N)也证实焦亡的发生。丁酸钠使上皮细胞分化标志物外皮蛋白和警戒素S100A9表达增加。结论:丁酸钠可能通过促进牙龈上皮细胞先分化,进一步促进其发生焦亡,释放细胞内警戒素S100A9,从而对牙周组织的炎症状态发生影响。
It is intended to provide a model mouse which is to be used for clarifying the functions of Gsdmd on intestinal epithelial cells and Gsdmd gene encoding the same. A mouse having a homozygote in which Gsdmd gene encoding Gsdmd has been knock-out on chromosome and not expressing Gsdmd is ...
CL594-66387 targets GSDMD in IF/ICC applications and shows reactivity with human samples. Tested Applications IF/ICC Application Description Tested Reactivity human Immunogen GSDMD fusion protein Ag16827 种属同源性预测 Host / Isotype Mouse / IgG2a Class Monoclonal Type Antibody Full Name gasdermin ...