Verteporfin conbined with light rapidly exhibits apoptotic changes reflected by caspase-3 and caspase-9 activation and PARP cleavage in HL-60 cells, changes that are blocked by the general caspase inhibitor ZVAD.fmk. In vivo Verteporfin can be used for angiographic visualization of choroidal vessels...
产品活性:Clofilium tosylate 是一种钾通道 (potassium channel) 阻滞剂,作用于人早幼粒细胞白血病 (HL-60) 细胞,激活 caspase-3 而诱导凋亡。具有抗心律失常作用。 研究领域:Membrane Transporter/Ion Channel | Apoptosis 作用靶点:Potassium Channel | Apoptosis In Vitro: HL-60 cells treated with Clofilium ...
产品活性:Clofilium (10 μM, 12 hours) induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17, and subsequent cleavage of its substrate PARP. However, there is no significant change in the expression of Bcl-2 and Bax proteins. HL-60 cells treated with Cl...
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产品活性:Clofilium tosylate 是一种钾通道 (potassium channel) 阻滞剂,作用于人早幼粒细胞白血病 (HL-60) 细胞,激活 caspase-3 而诱导凋亡。具有抗心律失常作用。 研究领域:Membrane Transporter/Ion Channel | Apoptosis 作用靶点:Potassium Channel | Apoptosis In Vitro: HL-60 cells treated with Clofilium ...