一项随机、双盲、多中心研究纳入395例3期CKD和无症状高尿酸血症患者。分为非布索坦组（n=203）与安慰剂组（n=192），根据蛋白尿和血清肌酐浓度分类，在无蛋白尿的亚队列中，非布索坦组的eGFR平均值显著高于安慰剂组(P= 0.007)研究结果提示，无蛋白尿者易出现临床肾硬化症，与安慰剂相比，非布索坦对无蛋白尿...
虽然最初认为IgA肾病的病程为良性,但目前发现多达50%的受累患者往往会在20-25年的观察期里缓慢进展为终末期肾病(end-stage renal disease, ESRD)[7]。其余患者进入持续的临床缓解期,或出现持续性低度血尿和/或蛋白尿。虽然可能难以预测一些患者的预后情况,但现已确定了肾病进展的重要危险因素。(参见下文‘疾病进展...
Congestive heart failure, coronary artery disease, stroke or peripheral vascular disease frequency was lower than 10% The prevalence of eGFR < 60 ml/min x 1.73 m(2) was: stage 3 (30-59 ml/min/1.73 m(2)) 19.7%; stage 4 (15-29 ml/min/1.73 m(2)) 1.2%; stage 5 no dialysis (...
The mean ADC values were recorded for each patient and the relationship between ADC values and stage of CKD and serum creatinine levels were evaluated. Statistically significant difference was determined between the ADC values of the cases according to CKD stages (p<0.001). Paired comparisons ...
Furthermore, by the time serum creatinine level is elevated, most kidney biopsy results show considerable interstitial fibrosis and tubular atrophy.5 Thus, to truly prevent CKD, we need more sensitive early markers before scarring, and presumably, irreversible damage occurs. Although albuminuria may ...
When cross-classified by the presence of proteinuria and serum creatinine level, the mean eGFR slopes significantly differed between the febuxostat and placebo groups (P = 0.040) in cross-classified subcohorts without proteinuria and with serum creatinine level ≥ median, but not in the cross-...
a) and the kidney showed significant increase in fibrosis (amount of Picrosirius Red staining) in the areas surrounding the microspheres (Fig.1c–e) as well as a significant rise in urinary NGAL in the CKD animals (Fig.1f). However, no proteinuria or changes in urine creatinine levels were...
Stage 3b: Moderate reduction in GFR (30-44 mL/min/1.73 m2) Stage 4: Severe reduction in GFR (15-29 mL/min/1.73 m2) Stage 5: Kidney failure (GFR < 15 mL/min/1.73 m2 or dialysis) KDIGO guidelines recommend using creatinine-based formulas for determining the estimated glomerular filtr...
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CKD指南：PCP指南，用于CKD检测和延缓进展说明书