We investigated the relationship between infiltrating citrullinated histone H3 (H3Cit)-positive (+) neutrophils and disease specificity and activity in various glomerulonephritis (GN). Methods and results: We selected 32 kidney biopsies with GN, including AAV, lupus nephritis (LN), Henoch-Schnlein ...
, 13.. Citrullinated histone H3 (H3Cit) has been proposed as a target biomarker reflecting NET formation 11., 12.. Other putative biomarkers for NETs include cell‐free DNA (cfDNA) and nucleosomes, which may also have other sources than NET formation, such as cellular decay or apoptosis. ...
In this study, we investigated whether citrullinated histone H3 (H3Cit) could serve as a biomarker for the detection of critical liver damage in sepsis and the efficacy of phosphodiesterase-III inhibition for preventing the liver dysfunction induced by NETosis.Mice injected with lipopolysaccharide (...
In this study, we investigated whether citrullinated histone H3 (H3Cit) could serve as a biomarker for the detection of critical liver damage in sepsis and the efficacy of phosphodiesterase-III inhibition for preventing the liver dysfunction induced by NETosis.Materials and methods Mice injected with...
We investigated the association between NET formation biomarkers (citrullinated histone H3 [H3Cit], cell-free DNA [cfDNA], and nucleosomes) and the risk of ATE and all-cause mortality in patients with cancer. In this prospective cohort study, H3Cit, cfDNA and nucleosome levels were determined ...
Conclusions: A model incorporating H3Cit, IL-8 and CRP has an excellent prediction ability for ICI response; thus, patients with a lower "risk score" selectively benefit from ICI treatment, which may have significant clinical implications for the early detection of an ICI response....
Increased CitH3 levels (first quartile vs. fourth quartile of H3Cit, odds ratio, 3.311, 95% confidence interval, 1.336–8.027; p = 0.011) were independently associated with a greater WML burden in the fully adjusted multivariable model. Similar results were found when the H3Cit was analyzed ...
Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patientscancerH3Citneutrophil extracellular trapsthrombosisvenous thromboembolismBackground: Neutrophil extracellular traps (NETs)...
Background Recent data propose a diagnostic and prognostic capacity for citrullinated histone H3 (H3Cit), a marker of neutrophil extracellular traps (NETs), in pathologic conditions such as cancer and thrombosis. However, current research is hampered by lack of standardized assays. Objectives We ...
The aim of this study was to investigate the relationship between infiltrating citrullinated histone H3 (H3Cit)-positive neutrophils and disease specificity and activity in various glomerulonephritides.Kimura, HidehitoMii, AkikoShoji, JunArakawa, YusukeShimizu, Akira...