DATA EXTRACTION: Data on clinical studies were summarized according to test measures, study duration and outcome of study. Pharmacokinetic and pharmacodynamic studies were summarized according to properties and interactions. Adverse reactions were extracted to outline citalopram's safety profile. DATA ...
3. Changes in levels of both metabolites varied by age of the animal, brain region and time after last injection. These patterns differed from previous studies of shorter duration citalopram exposure. 4. The data support the view that 5-HT and 5-HIAA levels are probably not dependently ...
The conditions and duration of treatment with citalopram tablets varied greatly and included (in overlapping categories) open-label and double-blind studies, inpatient and outpatient studies, fixed-dose and dose-titration studies, and short-term and long-term exposure. Adverse Reactions Associated with...
Acute administration of citalopram had no effect on the latency of first mount, latency of the first intromission, number of mounts with intromissions and the duration of mounts with intromissions (Fig. 1A–C). Chronic citalopram treatment caused an increase in the latency of the Discussion Se...
The conditions and duration of treatment with citalopram varied greatly and included (in overlapping categories) open-label and double-blind studies, inpatient and outpatient studies, fixed-dose and dose-titration studies, and short-term and long-term exposure. Adverse Reactions Associated with ...
it exhibits higher selectivity for the human serotonin transporter relative to the noradrenaline or dopamine transporters than any other currently available SSRl's. In the mouse forced swim test, the duration of immobility (which reflects antidepressant activity) for escitalopra...
However, there is an increased concern about the possible adverse effects of citalopram on the reproductive and endocrine functions (Sloot et al., 2009). According to the OECD guidelines for genotoxicity testing, the drugs that are used widely or over a long duration of time need to be tested...
Optimum duration not established; may require several months of therapy or longer. Periodically reassess need for continued therapy.Obsessive-Compulsive Disorder†OralInitially, 20 mg once daily. Gradually increase dosage according to clinical response....
The pooled analyses of placebo-controlled trials in adults with MDD or other psychiatric disorders included a total of 295 short-term trials (median duration of 2 months) of 11 antidepressant drugs in over 77,000 patients. There was considerable variation in risk of suicidality among drugs, but...
Smith, C.C.; Vedder, L.C.; Nelson, A.R.; Bredemann, T.R.; McMahon, L.R. Duration of estrogen deprivation, not chronological age, prevents estrogen’s ability to enhance hippocampal synaptic physiology.Proc. Natl. Acad. Sci. USA2010,107, 19543–19548. [Google Scholar] [CrossRef] [...