Abstract: Combination of the 5-HT-uptake inhibitor, citalopram, with 1–5-HTP induced a characteristic head shake syndrome in rats. This was blocked by a range of 5-HT antagonists, including the selective 5-HT2 antagonists, ketanserin and pirenperone and was also blocked by the α1-adrenoce...
The citalopram/5-HTP-induced head shake syndrome is correlated to 5-HT2 receptor affinity and also influenced by other transmitters.doi:10.1111/j.1600-0773.1984.tb01996.xJrn ArntJohn HyttelJens‐Jrgen LarsenActa Pharmacol Toxicol (Copenh)
R-citalopram inhibits functional and 5-HTP-evoked behavioural responses to the SSRI, escitalopram. Pharmacol Biochem Behav 77: 391–398. Article Google Scholar Schechter LE, Balanos FJ, Gozlan G, Lanfumey L, Haj-Dahmane S, Laporte AM et al (1990). Alterations of central serotonergic and ...
2. In both behavioural (potentiation of 5-hydroxytryptophan (5-HTP)-induced behaviour) and electrophysiological studies (inhibition of 5-HT-elicited ion currents in Xenopus oocytes expressing the human SERT (hSERT) R-citalopram inhibited the effects of S-citalopram in a dose-dependent manner. With...
The enantiomers of citalopram and N-demethylcitalopram have been investigated. Based on the inhibition of 5-HT uptake in vitro and the potentiation of 1-5-HTP in vivo the pharmacological activity resides in the (+)-enantiomers (the eutomers*) with the 1-(S) absolute configuration. In the...
5-HTPallopregnanoloneSome evidence would indicate that a serotonergic deficit may be involved in epileptogenesis. A preliminary trial of citalopram, a selective inhibitor of serotonin reuptake, was carried out. Citalopram 20 mg/day was given to 11 non-depressed patients with poorly controlled ...
Department of Pharmacology and ToxicologyActa Pharmacologica et ToxicologicaArnt J, Hyttel J, Larsen JJ (1984) The citalopram/5-HTP-induced head shake syndrome is correlated to 5-HT 2 receptor affinity and also influences by other transmitters. Acta Pharmacol Toxicol 55:363–376...