A 50-year-old man with small cell lung cancer developed aortic thrombosis during treatment with cisplatin and dexamethasone [ route of cisplatin administration not clearly stated; duration of treatments to reaction onset not stated ]. The man started receiving cisplatin 60 mg/m 2 on day 1 and ...
After several times of administration can cause allergic reaction which can occur within minutes after administration, being manifested as facial edema, wheezing, tachycardia, etc. The patients should be quickly subject to anti-allergy measures such as antihistamine and adrenocorticotropic hormone. There ...
Empty CellValueUnitsPrep. and Route of Admin.ReferenceComments AbsorptionCisplatinis not absorbed following oral administration. It is administered intravenously. Bioavailability Distribution Volume of Distribution11.5l/m2i.v.Reece et al (1987) Plasma Protein Binding90%i.v.DeConti et al (1973)Cisplatin...
The principal route of its excretion is via the kidney, and accumulation of cisplatin in the renal cortex has been demonstrated. Three to five days following administration of cisplatin to rats, degenerative changes appear in the proximal tubule, including cytoplasmic vacuolization, tubular dilatation ...
All cytotoxic drugs can induce nausea and vomiting depending on the type of agent, dose, route and schedule of administration [1]. This variability underlines the differences in mechanisms responsible for the difference in onset and duration of this side-effect. Cisplatin is one of the most widel...
Study of the effect of route of administration of mesenchymal stem cells on cisplatin-induced acute kidney injury in Sprague Dawley rats. Int J Stem Cells. 2016;9(1):79–89. Article CAS Google Scholar Sisi LU, Zhong X, Yang Y, Zou X, Liang X, Cai G. Effects of single dose of ...
Furthermore, OTULIN knockdown enhanced the inhibitory effect of cisplatin on osteosarcoma cell migration (Fig. 2i, j, m). Notably, OTULIN overexpression had no significant effect on the proliferative, invasive, or migratory capacities of osteosarcoma cells with or without cisplatin administration (Fig...
We report a rare case of hepatocellular carcinoma (HCC) for which intravenous administration of cisplatin (CDDP) was effective. A 48‐year‐old woman with recurrent HCC was admitted to our hospital. She had undergone right hepatectomy 1 year previously. A large tumor in the liver and multiple ...
We think the difference as to the species, the administrating route as well as the dosage for metformin we used may account for the discrepancy between ours and Sahu’s38. Many studies demonstrated that tubular cell apoptosis is one of the major mechanisms leading to cisplatin-induced acute ...
As a result of this, a large increase in tumor drug concentrations (tenfold or higher) could be achieved relative to administration of the same dose of free drug, (Maeda et al. 2000) thereby decreasing the massive systemic side effects of conventional chemotherapy. In our previous study on ...