Furthermore, PD-L1 expression on antigen-presenting cells (APCs) prevented CTLA-4-mediated trans-endocytosis of CD80. Atezolizumab (anti-PD-L1), but not anti-PD-1, reduced cell surface expression of CD80 on APCs, and this effect was negated by co-blockade of CTLA-4 with ipilimumab (anti...
Intrinsic PD-L1 promotes antitumor activity of CD8^(+)cytotoxic T lymphocytes via in cis interaction with CD80 cytotoxicimpaireddeathDear Editor,Programmed cell death-ligand 1(PD-L1)on tumor cells can inhibit CD8+cytotoxic T lymphocyte(CTL)-mediated antitumor response by trans-engagement with ...
并通过共振能量转移技术(FRET),CD28与B7之间表现为受体光漂白后供体光恢复,而CD28与PD-L1之间则较低。此外CD28与B7之间的FRET被一种CTLA4的免疫球蛋白abatacept减弱,这种免疫球蛋白能与B7紧密结合并阻断CD28与B7的相互作用,因此B7:CD28存在顺式作用。 02:cis-B7:CD28可刺激T细胞活性 研究人员构建稳定表达CD80和CD86...
本研究中对照组的ORR、mOS、mPFS和AEs与ABC-02研究结果相近;其次由于固定剂量的D 1.5 g+不同剂量和用法的T 300mg x1/T 75 mg x4联合CisGem方案在疗效数据上和3级以上的AEs相近,三组疗效均优于单药吉西他滨和T+D+吉西他滨,但是3级以上的AEs发生率较高,说明免疫检查点抑制剂无论是PD-L1(TOPAZ-1研究)...
Immunity文章上发表了题为“cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity”。文章研究了CD28共刺激受体在外周组织中的作用。CD28有两...
cytotoxic T lymphocytes via in cis interaction with CD80]]>doi:10.1002/cac2.12337Yuming DingChaojia ChenShuaiya MaXue ShengFangcheng ZhaoJiali PengHaoqing DongChunhong MaChunyang LiCancer Communications