Here we evaluated a circulating tumor cell (CTC) RNA biomarker for its potential to identify patients with mCRPC who may benefit from bavdeg in the phase 1/2 study despite the absence of AR T878X/H875Y mutations.Methods:Patients with mCRPC and disease progression after >1 prior novel ...
单CTC-RNA分析提供了一种建立每个采样细胞的整体生物学状态的方法,并且可以识别潜在的药物靶标以及疾病进展过程中重要的生物学过程(如EMT)的变化。RNA和DNA单细胞方法的整合将不可避免地有助于在潜在的遗传/表观遗传变化与RNA谱中出现的变化之间建立联系。(图中:Single-cell molecular profiling(单细胞分子图);蛋白...
循环肿瘤细胞(circulating tumor cell)简称CTC,通常把进入人体外周血的肿瘤细胞称为循环肿瘤细胞。 1869年,澳大利亚病理学家John Ashworth首次提出循环肿瘤细胞的概念。 1976年,Nowell将CTC的定义修正为:来源于原发肿瘤或转移肿瘤,获得脱离基底膜的能力并通过组织基质...
Circulating tumor DNA (ctDNA), on the other hand, encompasses molecular genetic and epigenetic information mirroring the genome or epigenome of the cell from which it originates. Please refer to our articleUncovering Drug Resistance in Cancer: Insights from ctDNA Sequencingfor more information. ...
Circulating tumor cell-derived preclinical models: current status and future perspectives Zuzana Kahounová, Markéta Pícková, Stanislav Drápela, Jan Bouchal, Eva Szczyrbová, Jiří Navrátil & Karel Souček Cell Death & Disease volume 14, Article number: 530 (2023) Cite this arti...
10 Extending to solid tumors such as NSCLC, MRD status is still determined using liquid biopsies based on these techniques, while tumor liquid biopsies mainly include ctDNA, circulating tumor cells (CTCs), circulating tumor RNA (ctRNA), exosomes, etc.11 When it comes to determining tumor load...
In brief, tumor DNA and RNA were isolated from FFPE sections, and DNA/RNA libraries were prepared. Purified libraries were sequenced using Ion Torrent PGM (Thermo Fisher Scientific). Sequence reads were aligned to the hg19 assembly and were called using Ion Reporter Software version 4.4 (for ...
RNA sequencing of pancreatic circulating tumor cells implicates WNT signaling in metastasis. Nature. 2012; 487 :510–513. This reference is cited only in the Supplementary material .Yu, M., Ting, D.T., Stott, S.L., et al. 2012. RNA sequencing of pancreatic circulating tumor...
RNA-Seq of Circulating Tumor Cells in Stage II-III Breast Cancer(II-III期乳腺癌中循环肿瘤细胞的RNA-Seq) 热度: detection of circulating tumor cells in peripheral blood from patients with gastric cancer using pirnas as markers 热度: CirculatingTumorCells:ApplicationasaBiomarkerforMolecularCharacterization...
RNA-Seq of Circulating Tumor Cells in Stage II-III Breast Cancer(II-III期乳腺癌中循环肿瘤细胞的RNA-Seq) 热度: prognostic and predictive value of circulating tumor cells and cxcr4 expression as biomarkers for a cxcr4 peptide antago.预后和预测价值的循环肿瘤细胞和趋化因子受体cxcr4表达作为 ...