Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824...
Circulating proteins (from serum or plasma) can be used for inexpensive and minimally invasive determination of disease risk, early diagnosis, treatment adjusting, prognostication and disease progression monitoring. We provide here a review of the main published studies on serum proteins in breast ...
Type 1 diabetes is a chronic, autoimmune disease characterized by the destruction of insulin-producing 尾-cells in the pancreas. Early detection can facilitate timely intervention, potentially delaying or preventing disease onset. Circulating proteins reflect dysregulated biological processes and offer ...
Chan, M.K., Cooper, J.D., Heilmann-Heimbach, S., Frank, J., Witt, S.H., Nothen, M.M., Steiner, J., Rietschel, M., Bahn, S., 2017. Associations between SNPs and immune- related circulating proteins in schizophrenia. Sci Rep. 7 (1), 12586....
Int J Dermatol 2007; 46: 206-209.Lai FJ, Sheu HM, Lee JY, Cheng CL, Chen W: Vesicular pemphigoid with circulating autoantibodies against 230-kDa and 180-kDa proteins, and additional autoantibodies against 97-kDa and 45-kDa proteins. Int J Dermatol 2007;46:206-9....
Separated proteins were further transferred to polyvinylidene difluoride (PVDF) membrane using a liquid transfer system (100 V, 45 min). After the blockage (5% dry milk suspension in 0.1% Tween 20 in Tris-buffered saline [TBS]), the membrane was first incubated for 2 hr at room temperature ...
These proteins demonstrated the most consistent associations with low energy, while GDF15, CST3, and CTSZ were significantly associated with all five frailty components (FDR-adjusted p < 0.05). In cis-MR analysis, GDF15 and SERPING1 showed potential causal effects on frailty.#Conclusion:Higher ...
Following systemic administration, liposomes are covered by a ‘corona’ of proteins, and preserving the surface functionality is challenging. Coating the liposome surface with polyethylene glycol (PEG) is the most widely used anti-opsonization strategy, but it cannot fully preclude protein adsorption....
residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine ...
These substances, termed adipokines, include leptin [3], adiponectin [4], resistin [5], lipocalin 2(LCN2) [6], fatty acid binding proteins (AFABP) [7], plasminogen activator inhibitor-1 [8], interleukin 6 (IL 6) [9], and various growth factors. They are considered to play an ...