在接受EV-circSCMH1的PT小鼠中,与接受EV-Vector小鼠相比,BrdU+/CD31+EC比例增加(图1g),表明circSCMH1有助于卒中后的血管再生。此外,通过测试内皮细胞(CD31)和周细胞(CD13)标记物的共定位,EV-circSCMH1治疗的动物梗死周围区域的周围细...
circSCMH1的环状RNA介导FTO去除磷酯磷酸酶3(Plpp3)的m6A甲基化,促进中风后脑部血管和运动功能恢复的分子机制。文章来自东南大学生命科学研究所姚红红老师于2023年1月发表在Nature Communication一篇文章, 题目名为“FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional ...
Circ-SCMH1 knockdown suppressed the half-maximal inhibitory concentration of DDP, colony formation, and migration/invasion in SCC-15/DDP and CAL-27/DDP cells, but promoted apoptosis rate and apoptotic proteins (Bax and cleaved-caspase-3) expression. However, silencing miR-338-3p abrogated above ...
circSCMH1 was delivered to the brain of photothrombotic (PT) nonhuman primates by EVs as described in Fig.1a. At day 28 after PT model induction, EV-circSCMH1-treated monkeys displayed
通过构建靶向中枢并且包裹circSCMH1的细胞外囊泡(Extracellular Vesicle,EV),发现circSCMH1-EVs显着促进不同脑卒中小动物模型(tMCAO,dMCAO和PT)脑损伤修复,并在非人灵长类动物脑卒中模型上证实circSCMH1-EVs可显着改善脑卒中恒河猕猴的神经功能损伤程度并促进运动功能恢复。进一步机制研究表明,circSCMH1可以通过与Me...
今天瑞禧小编要分享的内容是miR-342-5p基因/miR181a基因/miR-214基因/HGF基因/cir cRNA/miR205/circScmh1基因X修饰外泌体的研究制备,一起来看! 外泌体(exosome)是细胞分泌的纳米级(30-100 nm)囊泡,能够通过其携带的miRNAs,多肽和蛋白质等生物活性物质向临近或远距组织器官传递信息,影响细胞功能。因此,外泌体...
CircSCMH1 expression and HN1 abundances were increased, but the miR-485-5p level was reduced in SOR-resistant HCC tissues and cells. Deficiency of circSCMH1 enhanced SOR sensitivity by suppressing cell proliferation, migration, invasion, and glucose metabolism and inducing cell apoptosis in SOR-...