Meanwhile, in vitro air–liquid interface (ALI) models of respiratory tract tissue have also been improved to assess the genotoxicity, mutagenicity and cellular response of tobacco smoke particulate matter. These ALI models now display similar morphology and character to human in vivo tissue which ...
Cancer stem cells (CSCs), a small subpopulation of cancer cells, are critically implicated in tumor occurrence, growth, progression, metastasis, therapy resistance, relapse, and poor prognosis3,4. CSCs possess several distinct features including clonogenic ability, self-renewal, expression of stem cell...
Recent epidemiological studies demonstrate that both active and involuntary exposure to tobacco smoke increase the risk of breast cancer. Little is known, however, about the molecular mechanisms by which continuous, long term exposure to tobacco smoke contributes to breast carcinogenesis because most previ...
are associated with tobacco smoke exposure. Animals received cigarette smoke exposure for 6 h/day, 5 days/week for 9 months. Results reveal that the hematopoietic stem and progenitor cell (HSPC) pool size is reduced by cigarette smoke exposure. We next examined the effect of cigarette smoke exp...
Hematologic sequelae of tobacco smoke exposure include CD8+ cytotoxic T cell lymphocytosis and neutrophilia. BrdU labeling studies show decreased transit time through the post-mitotic pool of the bone marrow, consistent with chronic stimulation of hematopoiesis [3]. Despite the egress of maturing cells...