博士后期间揭示免疫受体对paired NLR CHS3/CSA1进化过程中形成两种调控模式,其中“保卫模式”进化上保守,并且两种调控模式的获得以“受体CHS3”和“执行者CSA1”共同进化为代价(Yang et al.Cell Host & Microbe 2022);解析paired NLR ...
The receptor kinases BAK1 and BIRs inhibit CHS3-CSA1 pair oligomerization to maintain the CHS3-CSA1 heterodimer in an inactive state. Our study reveals that paired NLRs hetero-oligomerize and likely form a distinctive "dimer of heterodimers" and that structural heterogeneity is expected even among...
博士后期间揭示免疫受体对paired NLR CHS3/CSA1进化过程中形成两种调控模式,其中“保卫模式”进化上保守,并且两种调控模式的获得以“受体CHS3”和“执行者CSA1”共同进化为代价(Yang et al.Cell Host & Microbe 2022);解析paired NL...
The CHS3/DAR4 sensor NLR, which functions together with its partner, the helper NLR CSA1, carries an integrated domain (ID) with homology to DA1 peptidases. Using domain swaps with several DA1 homologs, we show that the LIM-peptidase domain of the family member CHS3/DAR4 functions as ...
博士后期间揭示免疫受体对paired NLR CHS3/CSA1进化过程中形成两种调控模式,其中“保卫模式”进化上保守,并且两种调控模式的获得以“受体CHS3”和“执行者CSA1”共同进化为代价(Yang et al. Cell Host & Microbe 2022);解析paired NLR CHS3/CSA1的激活机制和多种寡聚化模式,通过CHS3/CSA1不同等位基因的研究,...