Cognitive infringements represent an actual problem of modern medicine. In elderly men they usually develop on a background of a chronic ischemia of brain (CHBI). P300 research in 134 patients was carried out to define CHBI influence on the basic components of the caused potentials. The group...
Objective To investigate the effect of chronic brain ischemia on the expression and activity of α-secretase in the hippocampus of rats. Methods Cerebral blood hypoperfusion rat model by bilateral common carotid artery permanent ligation was made. Y-maze test was conducted at 10 days, 30 days, 90...
Disruptions of the blood-brain barrier (BBB) and edema formation both play key roles in the development of neurological dysfunction in acute and chronic cerebral ischemia. Animal studies have revealed the molecular cascades that are initiated with hypoxia/ischemia in the cells forming the neurovascular...
Identification of vascular cues contributing to cancer cell stemness and function Article 03 February 2022 Introduction The human brain is a uniquely complex organ, with vast cellular diversity, intricate cytoarchitecture and macroscopic functional regionalization, all of which emerge due to precise spati...
It has been found that the inflammatory response in CKD patients directly or indirectly damages renal vascular endothelial cells, causes tubular injury and renal unit failure, and promotes the progression of CKD, which then activates the body’s defence mechanisms, resulting in the triggering of ...
Multimodality Imaging of the Brain-Heart-Axis after Ischemic Stroke Reveals Acute and Chronic Cardiac Dysfunction after Cerebral Ischemia Beyond neurological dysfunction, cerebral stroke also increases risk of subsequent cardiac events and development of chronic heart failure. The mechanisms underlying this b...
Oligovascular coupling contributes to white matter vascular homeostasis. However, little is known about the effects of oligovascular interaction on oligodendrocyte precursor cell (OPC) changes in chronic cerebral ischemia. Here, using a mouse of bilatera
are the primary sources for TNF-α synthesis. TNF-α synthesis is stimulated by a wide variety of agents. In macrophages, it is induced by biological, chemical, and physical stimuli such as viruses, bacterial and parasitic products, tumor cells, complement, cytokines, ischemia, trauma, ...
Chronic traumatic encephalopathy (CTE) is a recently revived term used to describe a neurodegenerative process that occurs as a long term complication of repetitive mild traumatic brain injury (TBI). Corsellis provided one of the classic descriptions of CTE in boxers under the name “dementia pugili...
of therapeutic agents in a wide range of chronic diseases, such as diabetes, cancer, atherosclerosis, myocardial ischemia, asthma, pulmonary tuberculosis, Parkinson’s disease, and Alzheimer’s disease. After successful outcomes in preclinical and clinical trials, many of these drugs have been ...