Hemispheric white matter microvascular ischemia has been the subject of research progress - advanced stages are known to cause gait disorder and dementia but early stages are associated with "idiopathic" dizziness in the elderly.doi:10.1097/WCO.0000000000001229Adolfo M.,Bronstein...
M. et al. Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study. Alzheimers Dement 13, 634–643 (2017). Article PubMed Central Google Scholar Promjunyakul, N. O. et al. Baseline NAWM structural integrity and CBF ...
It could benefit CKD patients to reduce the following CSVD and dementia through controlling blood phosphate levels and maintain TJ's function. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal ....
Chronic arterial hypertension is a significant risk factor for all-cause dementia, including neurodegenerative Alzheimer’s disease (AD) and vascular cognitive impairment (VCI). Cerebral small vessel disease (cSVD), attributed to arterial hypertension, is primarily characterized by arteriolosclerosis and ...
Moreover, the association of CKD with CI was stronger than that with extensive small vessel disease. There is a growing awareness that vascular dementia and degenerative dementia such as Alzheimer's disease share similar mechanisms and lesions.25–28 Accordingly, the possibility that factors other ...
(Fig.15a–c), the latter being indicative of ECM remodeling. Contiguous to a vessel undergoing ECM remodeling, we also identified a small apoptotic microglial cell with a small hollow nucleus and unfolded chromatin released into the cytoplasm (Fig.15c–f). Chromatin degradation may be responsible...
Vascular dementiaCerebral small vessel diseaseIn view of the high prevalence, cognitive abnormalities have a direct relevance in patients with chronic kidney disease. Characterized by cognitive slowing, attention deficits, disturbances in the planning, initiation and implementation of actions as well ...
One of the manifestations of cerebral small vessel disease are chronic brain infarcts, including cortical, subcortical, and lacunar infarcts; each with a different appearance on MRI14,15. Identification of these infarcts is important, because their occurrence is associated with vascular dementia, Alzheim...
AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia Article 09 December 2020 A novel rat model of cerebral small vessel disease based on vascular risk factors of hypertension, aging, and cerebral hypoperfusion Article 13 ...
The clinical diagnosis of vas- cular dementia (VaD) was made by the appearance of the following features: lacunae, multiple, cystic or border- zone infarcts, microinfarcts and small vessel disease, and could be pathologically confirmed as Braak stage ≤ IV [26, 28]. Cases were classified...