Despite the short-term success of heart transplantation, chronic rejection, or cardiac allograft vasculopathy (CAV), remains the leading cause of allograft failure after the 1st posttransplant year. CAV is a diffuse concentric form of coronary atherosclerosis that occurs in 40 to 50% of heart ...
New immunosuppressive agents may also influence chronic rejection. Therefore the objective of this study was to test the ability of cyclosporin A, FK-506 and mycophenolate mofetil to reduce chronic rejection in a rat cardiac transplant model. Heterotopic rat heart transplantation (Lewis to Fisher) ...
Background.The present study was devised to elucidate the influence of immunogenicity, immunosuppression, and ischemia on the development of transplant vasculopathy (TVP) as well as to investigate myointimal proliferation in syngeneic transplantation.Methods.Fischer 344 and Brown Norway rat heart allografts...
Mechanisms of chronic rejection in heart transplants: The role of T lymphocyte subsets. Chronic rejection, or cardiac allograft vasculopathy (CAV), remains the major obstacle to the long-term survival of heart transplant recipients. CAV is cha... Fischbein,Michael,Peter. - University of California...
High-sensitivity cardiac troponin I assay to screen for acute rejection in patients with heart transplant. Background—A noninvasive biomarker that could accurately diagnose acute rejection (AR) in heart transplant recipients could obviate the need for surveilla... PC Patel,DA Hill,CR Ayers,......
CHRONIC VASCULAR REJECTION OF THE HEART AND THE KIDNEY\\u2014HAVE RATIONAL TREATMENT OPTIONS EMERGED? 来自 国家科技图书文献中心 喜欢 0 阅读量: 30 作者:PAUL,L.,C.,FELLSTR\\udM,B.摘要: University of Calgary, Alberta, Canada.关键词: Humans Heart Transplantation Kidney Transplantation Arteries ...
1)chronic rejection慢性排斥反应 1.Function of TIMP-3 in arteriosclerosis of orthotopic transplant duringchronic rejection;TIMP-3在移植物慢性排斥反应血管病变中的作用研究 2.Histopathologic analysis ofchronic rejectionafter orthotopic liver transplantation;人类同种异体肝移植慢性排斥反应病理特点分析 ...
chronic rejection; cardiac transplantation Background: Chronic rejection is a risk factor for the development of cardiac allograft vasculopathy (CAV) in heart transplant recipients. A useful animal model to study the role of immunosuppressive strategies in the prevention of chronic rejection involves heter...
thereby contributing to graft dysfunction in the long term. Chronic rejection remains a major limitation to allograft longevity and patient survival. The alterations in the heart include the following: (1) vascular changes (starting at the microvascular level and progressing to epicardial vessels), (...
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 被引量: 15发表: 2008年 Rat cytomegalovirus infection and chronic kidney allograft rejection To investigate the effect of cytomegalovirus (CMV) infection on the ...