( 1989 ) Chronic myelomonocytic leukemia: natural history and prognostic determinants . Mayo Clinic Proceedings , 64 , 1246 1254 .Tefferi A, Hoagland HC, Therneau TM, Pierre RV. Chronic myelomonocytic leukemia: Natural history and prognostic determinance. Mayo Clin Proc 64:1246-1254, 1989....
Chronic myelomonocytic leukemia (CMML) is a rare, heterogeneous myeloid malignancy classified as a myelodysplastic syndromes/myeloproliferative neoplasm (MDS/MPN) overlap syndrome by the World Health Organization (WHO). Its initial presentation can be in
38% of patients progressed to overt chronic myelomonocytic leukemia (median: 12 months). The overall percentage of mutations was significantly lower in oligomonocytic chronic myelomonocytic leukemia. However, the most frequent mutations in both groups were the ‘signature’ chronic myelomonocytic leukemia ...
Division of HematologyMayo ClinicRochester MinnesotaJohn Wiley & Sons, LtdAmerican Journal of HematologyPatnaik MM, Wassie EA, Lasho TL, Hanson CA, Ketterling R, Tefferi A. Blast transformation in chronic myelomonocytic leukemia: risk factors, genetic features, survival, and treatment outcome. Am ...
Owing to its variable pathologic features and clinical course, chronic myelomonocytic leukemia (CMML) is both a diagnostic and a therapeutic challenge. The French-American-British (FAB) classification system included CMML as one of the five categories of myelodysplastic syndrome (1), and its definitio...
Chronic myelomonocytic leukemia (CMML) is a clonal myeloid disorder characterized by peripheral blood (PB) monocytosis (absolute monocyte count (AMC) ≥1 × 109/L and ≥10% of the total white blood cell count (WBC)) and overlapping features of myelodysplastic syndromes and myeloproliferative ...
it could be distinguished from chronic myeloid leukemia (CML), atypical chronic myeloid leukemia (aCML), and chronic myelomonocytic leukemia (CMML). Similarly, by eliminating potentially confounding underlying clinical conditions such as infections or malignancy it could, sometimes with difficulty, be diff...
5-azacytidinehematopoietic stem cell transplantationjuvenile myelomonocytic leukemiamyelodysplastic/myeloproliferative disordersRAS pathwaytargeted therapy... ML Strocchio - 《Expert Review of Hematology》 被引量: 1发表: 2018年 Low Dose Splenic Radiotherapy for Myeloproliferative Neoplasms prior to Allogeneic Hemat...
The syndrome of chronic myelomonocytic leukemia (CMML) includes a heterogeneous group of patients who exhibit both myelodysplastic and myeloproliferative clinicopathological features. Troublesome splenomegaly is uncommon in myelodysplastic syndrome (MDS), but when organomegaly occurs, this complication is more ...
Cleveland Clinic, Cleveland, OH, USA; 7Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA and 8Department of Pathology, Massachusetts General Hospital, Boston, MA, USA Chronic myelomonocytic leukemia is characterized by persistent absolute monocytosis (≥1...