monitoringpopulation‐basedprescriptionThere are established guidelines for treatment and monitoring of chronic myeloid leukemia (CML) but little is known about routine care. Data on ICD-10 codes as well as prescribed medications were available for 10.5million patients in the statutory health insurance ...
Complete removal of an ICD system carries considerable risk. In patients with a history of hematological disease, it is crucial to exclude cutaneous manifestations of the disease prior to device removal. 展开 关键词: Chronic lymphocytic leukemia Implantable cardioverter-defibrillator Pocket infection ...
cardiovascular disease or myeloid neoplasms, myeloid CH increased the risk of adverse outcomes in CKD (HR = 1.6,P = 0.002) compared to those without myeloid CH. Mendelian randomisation analysis provided suggestive evidence for a causal relationship between CH and CKD (P = 0.03). We...
Goldin, L. R., Pfeiffer, R. M., Li, X. & Hemminki, K. Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database.Blood104, 1850–1854 (2004). CASGoogle Scholar Di Bernardo, M. C. et al. A ge...
Acute myeloid leukemia CDC: Complement-dependent cytotoxicity CLL: Chronic lymphocytic leukemia CXCL12: C-X-C motif chemokine ligand 12 CXCR4: C-X-C chemokine receptor type 4 F-ara-A: Fludarabine PCD: Programmed cell death ROS: Reactive oxygen species SICD: Specific induced cell dea...
A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that pr...
45 Long-term follow-up data recently presented shows no increased risk of treatment-related acute myeloid leukemia (AML).24 An Italian phase 2 study of sequential FR confirmed good response rates, with 78% of patients achieving a CR, but only patients who had stable disease (SD) or better ...
CHRONIC myeloid leukemiaDASATINIBPROTEIN-tyrosine kinase inhibitorsTREATMENT effectivenessNATIONAL health insuranceOLDER patientsPurpose: This study aimed to provide real-world evidence on the characteristics, treatment patterns, and outcomes of patients with chronic myeloid leukemia (CML) r...
Mutations causing hyperactivation of the PI3K pathway are among the most common genetic lesions in human cancer27, and somatic mutations in the INPP5D gene encoding SHIP1 have been detected in acute myeloid leukemia (AML) patients28. These mutations strongly reduce SHIP1 activity, either by ...
e19058#Background:The treatment landscape for patients with relapsed and refractory (RR) chronic myeloid leukemia (CML) has changed significantly in recent years, with the introduction of targeted oral anticancer therapies. Current guidelines from the National Cancer Comprehensive Network (NCCN) recommend...