LeukemiaCMLMortalityTyrosine kinase inhibitorImatinib mesylateHematopoietic stem cellClonal disorderDefinition Synonym myelocytic leukemia, also chronic myelogenous leukemia a myeloproliferative disorder associated with clonal proliferation of cells of bone marrow stem cell origin with excessive production of mature-...
慢性粒细胞白血病(Chronic myeloid leukemia,CML),是一种起源于骨髓造血细胞并侵入血液的癌症。成人白血病中约15%是慢性粒细胞白血病。酪氨酸激酶抑制剂(TKI)有助于改变疾病的预后,与其他癌症治疗相比,副作用更少。然而,TKI只控制了疾病的发展,留下了产生耐药性的可能性。值得庆幸的是,来自广岛大学的研究人员报告说,...
Chronic myeloid leukemia (CML) is a blood cancer caused byBCRABL1in a cell with the biological ability, intrinsic or acquired, to cause leukemia [1].BCRABL1encodes a 210 KD chimeric protein (P210BCRABL1) with constitutive tyrosine-kinase activity [2,3]. By various incompletely defined mechan...
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm featured with uncontrolled proliferation of myeloid cells at every stage of differentiation [1]. CML is the first discovery of a link between cancer and chromosomal abnormality, which also called the Philadelphia (Ph) chromosome, d...
Chronic myeloid leukemia (CML) is defined as the clonal myeloproliferative disorder characterized by the expression of BCR-ABL fusion gene produced by reciprocal translocation of Philadelphia chromosome. From: European Journal of Medicinal Chemistry, 2021 ...
chronic-myeloid-leukemia-cml网络慢性骨髓性白血病;慢性粒细胞性白血病 网络释义 1. 慢性骨髓性白血病 技术服务详细描述 慢性骨髓性白血病(chronic myeloid leukemia CML)患者大多存在费城染色体〔Philadelphia chromosome…www.biomart.cn|基于2个网页 2. 慢性粒细胞性白血病 ...
Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission afte
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. It accounts for 20% o
Common Challenges in Treating Chronic Myeloid Leukemia Chronic Myelogenous Leukemia (CML) Treatment Sequencing in Patients With Ph+ Chronic-Phase CML Fact or Fiction: Chronic Myelogenous Leukemia (CML) Rapid Review Quiz: Chronic Myelogenous Leukemia (CML) Fast Five Quiz: How Much Do You Know...
It was then that he discovered he had Chronic Myeloid Leukemia (CML). CML is a cancer of the bone marrow and white blood cells. It is a form of leukemia that is characterised by an increased growth of myeloid cells in the bone marrow and ...