The recent American Society of Hematology (ASH) annual meeting, held in Orlando, Florida, in December 2019 was an exciting meeting for researchers and clinicians working in the field of chronic myeloid leukemia (CML), as well as for patients suffering from the disease. Interesting updates were ...
We are presenting a case report on an unreported and unusual cutaneous manifestation of chronic lymphocytic leukemia in a patient with an implantable cardioverter-defibrillator (ICD). A 65-year-old man with a history of chronic lymphocytic leukemia (CLL), previously treated with chlorambucil, was re...
SHORT COMMUNICATION British Journal of Cancer (2014) 110, 783–787 | doi: 10.1038/bjc.2013.780 Keywords: acute myeloid leukaemia; chronic lymphoid leukaemia; benzene; petroleum workers Acute myeloid and chronic lymphoid leukaemias and exposure to low-level benzene among petroleum workers L Rushton*,1...
master regulator of B versus T lymphoid fate. Loss ofZBTB7Aresults in aberrant activation of the NOTCH pathway in lymphoid progenitors. NOTCH is constitutively activated in CLL and is a determinant of resistance to apoptosis in CLL cells. rs34676223 at 1p36.11 maps∼10 kb upstream ofMDS2(F...
Overall, CXCR4 expression was significantly higher in CLL-B cells as compared to normal B or T cells (10- and 22-fold, respectively; p < 0.0001) (Fig. 1b). Furthermore, CXCR4 expression in leukemia and lymphoma cell lines including K562, MEC1, Namalwa, Raji, JeKo-1, and Jurkat...
Post-transplant lymphoproliferative disorder (PTLD) is a syndrome of uncontrolled lymphoid growth in the immunosuppressed transplant patient. Known risk factors include Epstein-Barr virus (EBV) seronegativity at the time of transplant, p... MA Nalesnik - Springer Berlin Heidelberg 被引量: 358发表: ...
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies. Curr. Opin. Hematol. 21, 341–349 (2014). Article CAS PubMed PubMed Central Google Scholar Kittai, A. S. & Woyach, J. A. Resistance mechanisms to targeted agents in chronic lymphocytic leukemia. Cancer J. 25,...
(n = 1611) is shown in Supplementary Table1. CH was defined as participants with any mCA and/or any somatic driver mutation; myeloid CH was defined as the presence of myeloid mCA and/or a myeloid somatic driver mutation(s); lymphoid was defined by lymphoid mCA and/or lymphoid ...
chronic lymphocytic leukemia;electronic health records;natural language processing;real-world evidence;artificial intelligence 1. Introduction Chronic lymphocytic leukemia (CLL) is characterized by the clonal proliferation and accumulation of mature and typically CD5-positive B-cells within the peripheral blood...
To be included, patients had to be at least 18 years of age with valid provincial coverage, diagnosed with CLL based on the ICD-O-3 histology code 9823/3-CLL or small cell leukemia, and survived more than 2 weeks after diagnosis. Patients were included if any of the following treatments...