Goldin, L. R., Pfeiffer, R. M., Li, X. & Hemminki, K. Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database.Blood104, 1850–1854 (2004). Google Scholar Di Bernardo, M. C. et al. A genome...
Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the suppression of oncogenic kinase signaling. Here, we test the hypothesis that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT (PI3K/AKT)-signaling pathway may be leveraged to trigger CLL cell death. Th...
(%) Myelodysplastic syndrome Acute myeloid leukemia Acute lymphocytic leukemia Primary myelofibrosis Mantle cell lymphoma Sideroblastic anemia Aplastic anemia n = 20 n = 14 (70%) n = 7 (35%) 63 ± 10 176 ± 10 80 ± 22 n = 5 (25%) n = 5 (25%) n = 4 (20%) n = 3 (15%) ...