Summary In the past 20 years, important progress has been made in the understanding of the natural history and prognosis of chronic lymphocytic leukaemia (CLL). Based on the notion that the clinical manifestations of CLL are due primarily to the progressive accumulation of lymphocytes over time, ...
B-cell chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy that is characterized by a monoclonal expansion of mature CD5+ B-cells. The morphology, immunophenotype and even gene expression profile of the malignant B-cells is relatively homogeneous, in contrast to the marked variability...
Chronic lymphocytic leukaemia (CLL) is a progressive, malignant disease of the blood-forming organs, marked by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Latest Research and Reviews Incidence of Richter transformation of chronic lymphocytic leu...
Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The mechanisms driving RT remain largely unknown. We characterized the whole genome, epigenome and transcriptome, combined with single...
Reddy KS. Chronic lymphocytic leukaemia profiled for prognosis using a fluorescence in situ hybridisation panel. British journal of haematology. 2006 Mar:132(6):705-22[PubMed PMID: 16487171] [46] Knuutila S, Elonen E, Teerenhovi L, Rossi L, Leskinen R, Bloomfield CD, de la Chapelle A....
Prognostic factors in chronic lymphocytic leukaemia: the importance of age, sex and response to treatment in survival : A REPORT FROM THE MRC CLL 1 TRIAL Summary. We report the analysis of prognostic factors in a cohort of 660 patients entered in the first Medical Research Council trial in ...
The research work presents an analysis of literature review and results of investigations on the problems of etiology, pathogenesis, classification and peculiarities of clinical manifestations of chronic lymphocytic leukaemia. Special attention is paid to both contemporary conceptions of carcinogenesis, ...
原著:《Chronic Lymphocytic Leukemia》 译著:《慢性淋巴细胞性白血病》 This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, ...
hairy‐cell leukaemiasplenic marginal zone lymphomanon‐Hodgkin's lymphomamonoclonal B‐cell lymphocytosisRichter's syndromesmall lymphocytic lymphomaprognosisThe term chronic B-cell lymphoproliferative disorders refers to several entities arising from mature B lymphocytes and which involve primarily the blood, ...
chronic lymphocytic leukaemia; lymph node biopsy; nuclear area; morphometry In 18 chronic lymphocytic leukaemia (CLL) and 2 diffuse, well-differentiated lymphoma (DWDL) lymp node biopsies, morphometric results analysing nuclear area distribution curves by the skewness coefficient were compared to histologi...