Areas covered:Currently, there are no specific targeted treatments for established ACLF, and management revolves around treating underlying precipitants and providing organ support. In this article, we review the epidemiology and pathophysiology of ACLF and summarize recent advances in management strategies...
Here, the authors evaluate the current status of potential treatments for ACLF and assess their efficacy and therapeutic potential. View article Acute-on-Chronic Liver Failure Zaid H. Tafesh MD, MSc, ... Nikolaos T. Pyrsopoulos MD, PhD, MBA, in Clinics in Liver Disease, 2023 Key points ...
Entecavir Versus Lamivudine Therapy for Patients With Chronic Hepatitis B-Associated Liver Failure: A Meta-Analysis BACKGROUND: analogues are recommended as antiviral treatments for patients with ()-associated liver failure. Clinical data comparing entecavir (ETV) and la... X Zhang,Y An,X Jiang,....
Advances in understanding its pathogenesis have lead to new treatments with improved outcomes. This article focuses on evidence-based management of renal failure in cirrhosis including hepatorenal syndrome, in the context of pathophysiological changes that occur.关键词:...
It is likely that a better definition will require new biomarkers, which will allow the development of new drugs and devices and, therefore, engagement with the industry will be crucial to bring these emerging treatments to patients. The liver transplant community will need to be engaged to ...
Acute liver failure may or may not be reversible, meaning that on occasion, there is a treatable cause and the liver may be able to recover and resume its normal functions. There are many types of liver disease. Liver disease caused by alcohol and cirrhosis ...
reachingamodelforend-stageliverdiseasescoreOf33pointswithinashortperiod;thisconditionwas complicatedwithhighlyactivevaricealbleedingandcoagulationsystemfailure(PT>100s1.Thepatientalso presentedhepatocellularcarcinoma.ComprehensivetreatmentsincludedefectiveinhibitionofhepatitisBvirus ...
This review addresses the different definitions developed by leading research groups, epidemiological and pathophysiological aspects, and the latest treatments for this entity.Keywords: acute-on-chronic liver failure, cirrhosis, organ failure, acute kidney injury, infection 展开 关键词: acute-on-chronic ...
Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and ... Background Effective treatments for acute-on-chronic liver failure (ACLF) are lacking. Human umbilical cord-derived mesenchymal stem cells (...
The HELIOS trial is the largest prospective randomized controlled clinical trial evaluating Prometheus therapy in patients with acute-on-chronic liver failure.7 In a multicentric approach, 145 patients underwent either standard medical therapy plus 8 to 11 Prometheus treatments during 21 days or standard...