Fig. 1: Illustrated overview of dentatothalamocortical pathway depicting a single deep brain stimulation lead implanted in the left dentate nucleus (brown). The crossed dentatothalamic projections (blue in upper-left illustration) terminate across multiple contralateral thalamic (green) nuclei that, in...
Presence of CSVD according to the modified STRIVE variable was defined as presence of at least one of the following: Fazekas scale ≥ 2, ≥ 1 lacunar infarct, ≥ 1 CMB, cortical atrophy, and/or central atrophy. Presence of central atrophy was visually assessed by an experienced neuro...
For example, anodal TDCS of the hand area in the primary motor cortex has been shown to improve motor performance of the affected hand (Allman et al., 2016, Hummel et al., 2005, Stagg et al., 2012) and anodal TDCS applied over the left frontal cortex enhanced naming accuracy in ...
Of the 79 subjects with subclinical lacunar infarction, 46 subjects (58.2%) had a single lacunar infarct. There were a total of 137 lacunae in 79 subjects: 73 were located in the basal ganglia, 15 in the thalamus, 39 in the corona radiata, 4 in the cerebellum and 6 in the brainstem....
After stroke in animal model, tonic neuronal inhibition is increased in the peri-infarct area. The increased tonic inhibition is caused by an impairment in GABA transporter (GAT-3/4) function and is mediated by extrasynaptic GABAA receptors (GABAARs). Treatment with benzodiazepine, an agonist for...
Left: Astrocyte’s prompt response. Acute O2 tension fall activates Ca2+ influx through TPRV1 channels, triggering the JAK2/STAT3 axis and NLRP3 inflammasome activation. It also increases BACE1 and IL-33 gene expression. Over-released IL-33 binds its STD2 receptor, whose signaling mitigates ...