Two APOL1 nephropathy variants confer substantial risk for non-diabetic end-stage kidney disease (ESKD) in African Americans (AAs). Since not all genetically high-risk individuals develop ESKD, modifying factors likely contribute. Forty-two potentially interactive single nucleotide polymorphisms (SNPs) ...
Electrolyte levels and acid-base balance:Kidney dysfunction causes imbalances inelectrolytes, especially potassium, phosphorus, and calcium.High potassium(hyperkalemia) is a particular concern. The acid-base balance of the blood is usually disrupted as well. Decreased production of the active form of vi...
My research also explores the balance between medication benefits and risks, showing that understanding these trade-offs can help personalize treatment and improve patient safety. For instance, certain newer drugs for CKD appear safer in terms of side effects like high potassium levels, while others ...
Chronic kidney disease has emerged as one of the leading causes of mortality worldwide, and it is one of a small number of non-communicable diseases that have shown an increase in associated deaths over the past 2 decades. The high number of affected individuals and the significant adverse ...
Common Medications for Diabetic Kidney Disease May Be Linked to Increased Risk of Hyperkalemia Erin Hunter, Assistant Editor November 4th 2023 Sodium-glucose cotransporter-2 inhibitors and sodium zirconium cyclosilicate may be paired with these kidney disease medications to reduce high serum potassium. ...
High blood pressure or heart disease Kidney infections or kidney stones Autoimmune diseases, such as lupus An enlarged prostate NSAIDs, illegal drugs, or smoking Family history of kidney diseaseWhat are the signs and symptoms of CKD?Signs and symptoms depend on how well your kidneys work. You ...
Consultation with a nutritionist is recommended for optimal dietary management and to avoid high-potassium foods. All patients with advanced CKD should be instructed to monitor their phosphorus levels and take phosphate binders with each meal.
Chronic Kidney Disease - Learn about the causes, symptoms, diagnosis & treatment from the Merck Manuals - Medical Consumer Version.
and normally the kidney helps with potassium excretion.In chronic kidney disease, just like with urea, less potassium is excreted and more builds up in the blood, and it leads to hyperkalemia, which is worrisome because it can cause cardiacarrhythmias.Another key role of the kidneys relates to...
Potassium supplementationMaintains normal muscle and heart function. (Tumil-K, Renacare) Blood pressure medicationLowers blood pressure. (Amlodipine) High blood pressure can occur secondary to kidney disease or can be a primary condition. In either case, it may worsen or cause the progression of ...