Small vessel diseaseLacunar strokeAfrican-AmericansChronic inflammationRace-ethnic disparitiesBiomarkersThe incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To ...
Chronic small vessel disease (SVD) has been shown to disrupt this network’s integrity and has been proposed as a predictor of poor outcome after stroke. We studied this hypothesis in patients with acute ischemic stroke of the striatocapsular region, an area of pronounced cortical and ...
et al. Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. J. Clin. Invest 120, 433–445 (2010). Article CAS PubMed PubMed Central Google Scholar Huang, Z. et al. Identification of a ...
? 2023 American Congress of Rehabilitation MedicineObjective: To determine whether MRI-based cerebral small vessel disease (cSVD) burden predicts treatment-induced aphasia recovery in chronic stroke patients above and beyond initial aphasia severity and stroke-lesion volume. Design: Retrospective. Four cSVD...
Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease. Theranostics 2019, 9: 4474–4493. Article CAS PubMed PubMed Central Google Scholar Boza-Serrano A, Ruiz R, Sanchez-Varo R, García-Revilla J, Yang Y, Jimenez-Ferrer I, et al. Galectin-3, a novel endogenous...
Cerebral small vessel disease can be identified using magnetic resonance imaging, and includes white matter hyperintensities, lacunar infarcts, cerebral microbleeds, and brain atrophy. Cerebral small vessel disease and chronic kidney disease share many risk factors, including hypertension. This study aims ...
A novel rat model of cerebral small vessel disease based on vascular risk factors of hypertension, aging, and cerebral hypoperfusion Article 13 June 2024 APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β ...
Chronic limb ischemic diseases mainly consist of Buerger’s disease, diabetic foot, and arteriosclerosis obliterans. Buerger’s disease is a non-atherosclerotic disorder characterized by occlusive and inflammatory lesions of medium and small arteries and veins [24]. Diabetic foot ulcers are usually cause...
It is in general difficult to predict which patient with stable ischemic heart disease will receive interventional or surgical revascularization in the long term, after initially being treated with optimal medical therapy (OMT). In the occluded artery trial (OAT), late opening of infarct-related art...
Renal dysfunction and risk of ischemic stroke or TIA in patients with cardiovascular disease. Neurology 2006; 67: 224–228. 3 Khatri M, Wright CB, Nickolas TL, Yoshita M, Paik MC, Kranwinkel G, Sacco RL, DeCarli C. Chronic kidney disease is associated with white matter hyperintensity ...