原发性慢性肉芽肿病(chronic granulomatous disease,CGD)是一组罕见的原发性免疫缺陷病( primary immunodeficiency diseases,PID),为先天性吞噬细胞(包括中性粒细胞、单核细胞、巨噬细胞和嗜酸性粒细胞)功能缺陷的典型疾病,由于基因突变导致吞噬细胞呼吸爆发功能障碍,不能杀伤过氧化物酶阳性的细菌和真菌,以反复细菌、真菌...
一、疾病慨述 原发性慢性肉芽肿病(chronic granulomatous disease,CGD)是一组罕见的原发性免疫缺陷病( primary immunodeficiency diseases,PID),为先天性吞噬细胞(包括中性粒细胞、单核细胞、巨噬细胞和嗜酸性粒细胞)功能缺陷的典型疾病,由于基因突变导致吞噬细胞呼吸爆发功能障碍,不能杀伤过氧化物酶阳性的细菌和真菌,...
chronic granulomatous disease is a rare disorder of phagocyte oxidative metabolism. The disease is characterised by recurrent infections in childhood that require prolonged courses of antimicrobial therapy. Adjunctive therapy with interferon-γ has been shown to reduce the frequency and severity of ...
Chronic granulomatous disease (CGD) is a rare congenital immunodeficiency characterized by recurrent bacterial and fungal infections as well as granuloma formation. The manifestations of this disease can involve single or multiple organ systems. The lungs are the most commonly affected organ; however, ...
Chronic granulomatous disease is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds used to kill certain ingested pathogens. This leads to the formation of granulomata in many organs. CGD affects about 1 in 200,...
原发性慢性肉芽肿病(chronic granulomatous disease,CGD)是一组罕见的原发性免疫缺陷病( primary immunodeficiency diseases,PID),为先天性吞噬细胞(包括中性粒细胞、单核细胞、巨噬细胞和嗜酸性粒细胞)功能缺陷的典型疾病,由于基因突变导致吞噬细胞呼吸爆发功能障碍,不能杀伤过氧化物酶阳性的细菌和真菌,以反复细菌、真菌...
摘要原文 Chronic granulomatous disease (CGD) is a primary immunodeficiency that affects phagocytes of the innate immune system and is characterized by a greatly increased susceptibility to severe bacterial and fungal infections. CGD is caused by mutations in any one of four genes that encode the sub...
原发性慢性肉芽肿病(chronic granulomatous disease,CGD)是一组罕见的原发性免疫缺陷病( primary immunodeficiency diseases,PID),为先天性吞噬细胞(包括中性粒细胞、单核细胞、巨噬细胞和嗜酸性粒细胞)功能缺陷的典型疾病,由于基因突变导致吞噬细胞呼吸爆发功能障碍,不能杀伤过氧化物酶阳性的细菌和真菌,以反复细菌、真菌...
Chronic granulomatous disease (CGD) is a paradigm for nonlymphoid primary immune defects, and has guided elucidation of oxygen metabolism in the phagocyte, vasculature, and brain. It has been in the forefront of the development of antimicrobial prophylaxis before the advent of advanced HIV and befor...
According to the United States Library of Science, ʺchronic granulomatous disease (CGD) is a genetic disorder in which certain immune system cells are unable to kill some types of bacteria and fungi. The disorder leads to long term (chronic) and repeated (recurrent) infections. The condition...