Granulomatous diseaseProtein structureChronic granulomatous disease is an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal infections and disordered inflammation. We propose that NADPH oxidase has a key role in regulating acute neutrophilic and T cell responses, which in...
The underlying cellular mechanism that causes chronic granulomatous disease was discovered in 1967, and research since that time has further elucidated the molecular mechanisms underlying the disease.doi:10.1007/s12016-009-8136-zSteven M. Holland
原发性慢性肉芽肿病（CGD）是一种罕见的先天性免疫缺陷病，其核心特征为吞噬细胞功能障碍，尤其是NADPH氧化酶复合物缺陷，导致细菌和真菌杀伤能力丧失。这一缺陷表现为反复感染，特别是细菌、真菌感染和肉芽肿形成。病原体入侵后，由于无法产生超氧化物等活性物质，吞噬细胞无法有效杀灭病原体，从而引发各种...
一、疾病慨述 原发性慢性肉芽肿病(chronic granulomatous disease,CGD)是一组罕见的原发性免疫缺陷病( primary immunodeficiency diseases,PID),为先天性吞噬细胞(包括中性粒细胞、单核细胞、巨噬细胞和嗜酸性粒细胞)功能缺陷的典型疾病,由于基因突变导致吞噬细胞呼吸爆发功能障碍,不能杀伤过氧化物酶阳性的细菌和真菌,...
Chronic Granulomatous Disease is the most commonly encountered immunodeficiency involving the phagocyte, and is characterized by repeated infections with bacterial and fungal pathogens, as well as the formation of granulomas in tissue. The disease is the
Chronic granulomatous disease (CGD) is a rare congenital immunodeficiency characterized by recurrent bacterial and fungal infections as well as granuloma formation. The manifestations of this disease can involve single or multiple organ systems. The lungs are the most commonly affected organ; however, ...
原发性慢性肉芽肿病(chronic granulomatous disease,CGD)是一组罕见的原发性免疫缺陷病( primary immunodeficiency diseases,PID),为先天性吞噬细胞(包括中性粒细胞、单核细胞、巨噬细胞和嗜酸性粒细胞)功能缺陷的典型疾病,由于基因突变导致吞噬细胞呼吸爆发功能障碍,不能杀伤过氧化物酶阳性的细菌和真菌,以反复细菌、真菌...
Chronic granulomatous disease is an inherited disorder of the NADPH oxidase characterized by severe bacterial and fungal infections and disordered inflammation. We propose that NADPH oxidase has a key role in regulating acute neutrophilic and T cell responses, which in turn restrains fungal growth and...
原发性慢性肉芽肿病(chronic granulomatous disease,CGD)是一组罕见的原发性免疫缺陷病( primary immunodeficiency diseases,PID),为先天性吞噬细胞(包括中性粒细胞、单核细胞、巨噬细胞和嗜酸性粒细胞)功能缺陷的典型疾病,由于基因突变导致吞噬细胞呼吸爆发功能障碍,不能杀伤过氧化物酶阳性的细菌和真菌,以反复细菌、真菌...
Bridges RA, Berendes H, Good RA (1959) A fatal granulomatous disease of childhood: the clinical, pathological and laboratory features of a new syndrome. Am J Dis Child 97:387–408 CASGoogle Scholar Quie PG, White JG, Holmes B, Good RA (1967) In vitro bactericidal capacity of human polymo...