Living long is a biological process characterized by progressive alterations in tissue/organ function, often associated with increased risk of chronic diseases. Among major theories...
1993 Role of insulin resistance in human disease (syndrome X): an expanded definition A. Rev. Med. 44: 121–131 CAS Google Scholar Remacle-Bonnet MM, Garrouste FL, Heller S, Andre F, Marvaldi JL, Pommier GJ . 2000 Insulin-like growth factor-1 protects colon cancer cells from death ...
Similar results were seen with infliximab in the Anti-TNF-α in Congestive Heart Failure (ATTACH) trial, which also demonstrated increased death in patients with HF at higher doses, presumably through the lysis of cells expressing TNF-α, such as cardiomyocytes.46 However, one wonders, if ...
NAFLD is the most common chronic liver disease, currently estimated to affect more than 25% of the global population [56]. The condition may be considered a hepatic manifestation of the metabolic syndrome as it is often implicated with other features, such as insulin resistance (IR), obesity a...
[70]. The result from the first phase of clinical trials also demonstrates multiple doses of MSCs to be safe when administered in COPD patients while reducing the C-reactive protein at 1 month after transplantation [83]. A study in elastase-induced emphysema demonstrated that two doses of ...
Abbreviations: LFT: lung functional test; BAL: Broncho-Alveolar Lavage; DLCO: Diffusion Lung Carbon Monoxide; FEV1: Forced Expiratory Volume in the first second; VC: vital capacity; BOS: Bronchiolitis obliterans syndrome; RLD: Restrictive Lung Disease; PDN: Prednisone; FAM: Fluticasone-Azithromycin-...
OSA, in particular CIH and SF, have been correlated with different metabolic disorders, including obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D) [5,6]. The association between OSA and dysmetabolism have been demonstrated in different clinical and epidemiological studies. MetS is ...
1. Introduction Orofacial pain conditions are very common and many that are chronic may be es- pecially difficult to diagnose and treat because of their complexity and lack of clarity of the detailed mechanisms underlying their aetiology and pathogenesis [1–6]. Examples are temporomandibular ...
Local immune activity in acute coronary syndrome: oxLDL abrogates LPS-tolerance in mononuclear cells isolated from culprit lesion. Int. J. Cardiol. 2013, 169, 44–51. [CrossRef] 9. Leoni, G.; Soehnlein, O. (Re) Solving Repair After Myocardial Infarction. Front. Pharmacol. 2018, 9, 1342...
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