High Rates of Atherosclerotic Disease-Related Mortality in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia Patients Associated with TET2-MutationsIntroduction: Clonal hematopoiesis of indeterminate potential (CHIP) is a situation where asymptomatic clonal genetic alterations are present in the blood ...
The role of inflammation is crucial in starting, advancing, and destabilizing atherosclerotic plaques. There is a strong consensus that systemic inflammation is associated with inflammation in the vascular walls [21]. The activation of lymphocytes and monocytes is crucial in the early phases of athero...
patients with LDL-C levels of ≥190 mg/dL, patients aged 40 to 75 years with diabetes who have LDL-C levels of 70–189 mg/dL, and patients without diabetes aged 40 to 75 years who have an estimated 10-year atherosclerotic cardiovascular disease risk of ≥7.5% and who have LDL...
Finally, in cases where ML-GPS targets cannot be directly modulated, indirect modulation or substrate delivery may still be possible: for example, ML-GPS identifies NOS3 (endothelial nitric oxide synthase) for CV_401.2 (hypertensive heart disease; score increase from 0.22 to 0.67), and organic n...
Low-grade subclinical inflammation affects endothelial function and is involved in all stages of the atherosclerotic process6. In fact, several studies have associated increased expressions of various markers of inflammation with the onset and severity of ED7. Erectile dysfunction (ED), defined by the...
The occurrence of chronic conditions in the CKD population was prevalent, with hypertension occurring in more than half the CKD patients.Conclusion: Several chronic conditions, especially those regarding atherosclerotic risk factors, frequently co-occurred with CKD. Lifestyle management and frequent ...
Atherosclerotic cardiovascular disease (ASCVD) and chronic kidney disease stage 3 - 4 (CKD) affects 7% and 10% of the Danish population, respectively. Systemic inflammation (SI) contributes to destabilisation of atherosclerotic plaques and is characterized by elevated levels of C-reactive protein (CRP...
It has also been suggested that magnesium has anti-atherosclerotic effects, and that hypomagnesemia promotes calcification in vascular smooth muscle cells [22], as well as endothelial cell dysfunction [17]. Our findings are consistent with the literature whereas hypomagnesemia was indeed associated with...
Myocardial infarction or other evidence of atherosclerotic disease appears to be less common in HF with normal LVEF, but hypertension is at least as common in this subgroup. The morbidity and mortality associated with HF and a relatively preserved LVEF may be nearly as profound as that with low...
Chronic inflammation is a major cause of cancer worldwide. Interleukin 33 (IL-33) is a critical initiator of cancer-prone chronic inflammation; however, its induction mechanism by environmental causes of chronic inflammation is unknown. Herein, we demons