Chromosomal instability (CIN) is widespread in human tumours and drives cancer evolution. Here, the authors present a computational cell-cycle model that generates CIN patterns from end-joining repair and repli
Using single-cell DNA sequencing after an error-prone mitosis in untransformed, diploid cell lines and organoids, chromosomes are shown to have different segregation error frequencies that result in non-random aneuploidy landscapes. Sjoerd J. Klaasen ...
Define the following medical term: Bilateral What would happen if DNA replication occurred again before meiosis II? Explain. Identify the term from the following definition: A single-celled structure formed after fertilization. Define the following term: dorsal Define mediastinum. Describe the events th...
Answer and Explanation: During S phase, the DNA in a cell is replicated. Since there are normally 46 chromosomes, and this number is doubled after S phase, human cells now have 92 chromosomes.Insert context header here:Insert context explanation here......
The absence of a large number of SNPs shared across clades suggests that the radiation of species occurred very quickly after the emergence of the new sex determiner. Therefore, most of the sequence differentiation in the sex-determining region has occurred independently in each lineage. The ...
Chromosoma - Puro, Nokkala - 1977 () Citation Context ...ng this phase is not known. However, we favor the speculation that the bivalent meiotic chromosomes are aligned before NEB in a polar array within a structure termed the chromocenter (Novitski, 1964; =-=Puro and Nokkala, 1977-=-)...
DNA replication is restricted to the S, or synthesis, phase during the cell cycle , between mitotic divisions. As a result of replication, each chromosome Figure 3. Telomerase is a hybrid protein-RNA molecule; the RNA sequence is complementary to several repeat lengths of the telomeric DNA. ...
2B). Our results show that the average diameters before and after expansion were 1.4 μm and 4.9 μm, respectively, representing an expansion index of 3.5 (Fig. 2C). Since the LSM980 microscope with AiryScan 2 has a resolution of approximately 90–120 nm, we estimate that the resolution ...
(Supplementary Fig.3b). H2B-Halo was stably expressed in the cell. Two hours after the addition of IAA (indole-3-acetic acid, auxin), SMC2 was almost completely depleted in the observed mitotic cells (Fig.4b,c). The resultant chromosomes showed abnormal shapes while still keeping a ...
Therefore, it is crucial to directly compare the mechanics of the same chromosome before and after manipulation. Fig. 1: Optical tweezers experiment to examine in situ ion-mediated chromosome condensation and histone depletion. a, Schematic of the experiment: the multichannel flow cell enabled us ...