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we projected the positions of all attached KMT ends on to the plane of cell division. There were 6 to 50 KMTs attaching to each of the 12 chromosomes per pole-facing side (Fig. 1j). Despite the larger kinetochore region, this is surprisingly close to the number...
We also found that kinetochore-targeted BHC module (BUB-1/HCP-1/2CENP-F/CLS-2CLASP) participated in efficient assembly of central spindle microtubules in anaphase, but did not play a significant role on its own in chromo- some orientation or congression prior to anaphase onset. Unex- pec...
In female gametes, accurate segregation of homologous chromosomes and sister chromatids, during the first and second meiotic divisions respectively, is essential to avoid generating aneuploid eggs1. Fertilization of aneuploid oocytes is a major cause of infertility in humans, as it usually leads to sp...
What is the second stage of mitosis, where the nuclear membrane dissolves and chromosome pairs align in the center of the cell? A cell has 46 chromosomes at each pole in mitotic telophase. In this division, what was the number of chromatids at ...
We also found that kinetochore-targeted BHC module (BUB-1/HCP-1/2CENP-F/CLS-2CLASP) participated in efficient assembly of central spindle microtubules in anaphase, but did not play a significant role on its own in chromo- some orientation or congression prior to anaphase onset. Unex- pec...
In mitotic cells (Fig. 3a; Supplementary Movie 1), 10 holocentric chromosomes align along the metaphase axis and each is attached to the spindle at various sites in a bipolar manner (amphitelic attachment). The kinetochores can be visualized all along the chromosome as parallel axes of CENH3...
(A) Initial position of chromosomes with respect to spindle poles defines motor-dependent (peripheral polar) and independent (central) regions important for chromosome alignment during early prometaphase. Different pathways to chromosome alignment to spindle midplane, noted with a circled number, are ...
(A) Initial position of chromosomes with respect to spindle poles defines motor-dependent (peripheral polar) and independent (central) regions important for chromosome alignment during early prometaphase. Different pathways to chromosome alignment to spindle midplane, noted with a circled number, are ...