Alteration in chromosome numbers and structures instigate and foster massive genetic instability. As Boveri has seen a hundred years ago (Boveri, 1914; 2008), aneuploidy is hallmark of many cancers. However, whether aneuploidy is the cause or the result of cancer is still at debate. The molecula...
1. The mutation targeted an enzyme highly active in cancer cells called telomerase, which helps to preserve chromosome structures during the corrosive process of cell replication. 2. Her study suggests that chromosome 11 may carry a tumour suppressor gene and have a pathogenic role in ovarian cance...
We similarly explored the effects of both X and Y chromosome numbers within sex. Results of shape-based metrics were analyzed using permutation tests consisting of 5,000 iterations. Results Several subregional areas, local curvature, and BLDs differed between groups. Moderate associations were found...
15). These data revealed that the genome structures of polyploid species were A1A2B1 (Mi and Ma 3n) and A1A2B1B2 (Ma 4n and Mj). Identification of putative novel telomeric repeats in Meloidogyne genomes Clade I RKNs are characterized by a dynamic karyotype with chromosome numbers less than...
Fig. 2: Gene families and evolution inS. albumandS. yasi. aPhylogenetic tree of 16 species including divergence times based on 305 single-copy nuclear genes. Divergence times are indicated by the numbers at each node with 95% highest posterior density. Names in light blue indicate rosid specie...
Chromosomal instability (CIN) is a characteristic ofcancercells with defects in segregations of chromosomes causing altered chromosome numbers in cells[46]. Solid tumors show mal-oriented attachment of chromosome to microtubule causing defects inchromosome segregationand aneuploidy. This mal-orientation is...
(Supplementary Fig.6a, b). Unlike great apes, both monomeric and dimeric repeat structures from the macaque group together and are sister clades to the monomeric ape clades, which suggests a common ancient origin restricted to these flanking pericentromeric regions. We used the orthology of ...
1. An extensive chromosome survey was carried out for the purpose of elucidating the actual variation procedure in chromosome structures of the present-day chrysanthemums, cultivated exclusively in Japan and especially for the exhibition use. 2. The cultivars of chrysanthemum used for the present study...
numbers of not only the different genera but also within the species of the same genus.The two big chromosomes seen regularly during prophase in the root-tip cells of Calathea medeo-picta are interpreted as compound structures and the occurrence of 23 chromosomes in some cells of the root-tip...
11% of the genes were differently expressed in at least one haplotype, where 25% of them were likely regulated through allele-specific DNA methylation. Our work sheds light on the recent breeding history of potato, the functional organization of its tetraploid genome and has the potential to str...