Chromosomal Microarray Analysis (CMA) testing for chromosomal and severe genetic conditions not detected by traditional chromosome analysis
Chromosomal microarray analysis has replaced conventional G-banded karyotyping due to its greater sensitivity and resolution; G-banding effectively identifies imbalances of DNA greater than 5 to 10 megabases (millions of base pairs), whereas CMA can detect genome-wide imbalances of more than 400 ...
Chromosomal microarray analysis (CMA), also known as array CGH, is a diagnostic test that can detect clinically significant major chromosomal imbalances (aneuploidies) and sub microscopic (microdeletion / microduplication) copy number variations throughout the genome. Chromosomal microarray analysis is th...
Chromosomal microarray testing revealed that this patient had a very rare and unusual form of acute myeloid leukemia that first appears as tumor masses that are often presumed to be solid tumors. Dr. Raca's team conducted a small study with these types of cancers, in ...
To investigate the incidence and clinical significance of chromosomal mosaicism (CM) in prenatal diagnosis by G‐banding karyotyping and chromosomal microarray analysis (CMA). This is a singleヽentre retrospective study of invasive prenatal diagnosis for CM. From 5758 karyotyping results and 6066 CMA ...
chromosomal microarray analysiscopy‐number variantsexpanded NIPSnon‐invasive prenatal screeningnon‐invasive prenatal testingrare aneuploidiesObjective: To evaluate the utility of expanded noninvasive prenatal screening (NIPS) for detection of chromosomal abnormalities in high-risk pregnancies compared with ...
Chromosomal array analysis has become the main molecular detection technology in addition to karyotyping. Chromosomal microarray analysis (CMA) as a diagnostic technique. With the development of next-generation sequencing technology, non-invasive prenatal testing (NIPT) technology based on cell-free foetal...
The purposes of this study is to examine possibility to use combination of non-invasive prenatal testing (NIPT) and chromosomal microarray analysis (CMA) for prenatal diagnostics and their advantages between combined first-trimester screen with confirmation by karyotyping of CVS or amniocytes. A total...
The aim of this retrospective study was to investigate the current applications of chromosomal microarray analysis (CMA) in foetuses with ventriculomegaly. A total of 548 foetuses with ventriculomegaly detected by prenatal ultrasound underwent single nucleotide polymorphism (SNP) array testing and were ...
The introduction of highly sensitive testing such as chromosomal microarray has generated additional kinds of uncertainty into the prenatal period. Counselors may feel uncomfortable or inadequately prepared to engage in discussions with prospective parents who are faced with making critical, and timely, ...