In eukaryotes, the deoxyribonucleic acid (DNA) molecule is associated with nuclear proteins called histones to form chromatin. This structure is not only essential to compact DNA to fit into the cell nucleus but also contributes to the regulation of DNA- dependent molecular mechanisms. Epigenetic ...
In eukaryotes, DNA is tightly wound into a complex called chromatin. Thanks to the process of chromatin remodeling, this complex can be "opened" so that specific genes are expressed. AaAaAa Chromatin If theDNAstrand in a single humancellwere stretched out, it would measure several meters in ...
Chromatin structure, and in particular highly-condensed chromatin, is generally inhibitory to transcription, replication and DNA repair. Therefore, all eukaryotes face another challenge, namely, to counteract the inhibitory effects of chromatin in order to accomplish these essential cellular processes [1,...
The structural organisation of chromatin in eukaryotes plays an important role in a number of biological processes. Our results provide a comprehensive insight into the nuclear topography of human peripheral blood granulocytes, mainly neutrophils. The nuclei of granulocytes are characterised by a segmented...
In eukaryotes, the accessibility of large regions of DNA can depend on its chromatin structure, which can be altered as a result of histone modifications directed by DNA methylation, ncRNA, or DNA-binding protein. Hence these modifications may up or down regulate the expression of a gene...
This animation starts by depicting both the protein and DNA components of the nucleosome, which is the fundamental unit of chromatin structure in eukaryotes. The eight histone proteins are shown in green, and the DNA helix in blue and white. The canonical nucleosome core particle consists of 147...
in all these areas have enabled researchers to image the genome with unprecedented spatial and temporal resolution. In this review, we focus on what single-molecule imaging and tracking of individual proteins in live cells have taught us about chromatin structure and dynamics. Starting with the ...
Higher-order chromatin structure: looping long molecules Chromatin structure plays a variety of roles in eukaryotes, ranging from the structural organization of the genome to the facilitation of transcription fac... Anna-Lisa,PaulRobert,J.,... - 《Plant Molecular Biology》 被引量: 27发表: 1999年...
Chromatin changes dynamically in the growth and development of eukaryotes, so changes in the external environment or the internal environment of the body can cause mutations in gene loci and even induce diseases. There has been substantial research evidence that chromatin modifiers play an integral rol...
Alterations in the chromatin structure are preferentially involved in the regulation of cell functions, including gene expression, in eukaryotes. Three types of mechanisms, by which the alterations are caused have been reported: (i) variants of histone subtypes, (ii) chromatin remodeling, and (iii)...