In eukaryotes, the deoxyribonucleic acid (DNA) molecule is associated with nuclear proteins called histones to form chromatin. This structure is not only essential to compact DNA to fit into the cell nucleus but also contributes to the regulation of DNA- dependent molecular mechanisms. Epigenetic ...
Chromatin structure, and in particular highly-condensed chromatin, is generally inhibitory to transcription, replication andDNA repair. Therefore, all eukaryotesfaceanother challenge, namely, to counteract the inhibitory effects of chromatin in order to accomplish these essentialcellular processes[1,2]. An...
In eukaryotes, DNA is tightly wound into a complex called chromatin. Thanks to the process of chromatin remodeling, this complex can be "opened" so that specific genes are expressed. AaAaAa Chromatin If theDNAstrand in a single humancellwere stretched out, it would measure several meters in ...
While these bacteria lack the chromatin structure found in eukaryotes that would ultimately be the namesake of the technique, by identifying specific RNA polymerase binding sites within the bacterial genome, Gilmour and Lis (1984) demonstrated that protein-DNA interactions could be fixed by covalent ...
This animation starts by depicting both the protein and DNA components of the nucleosome, which is the fundamental unit of chromatin structure in eukaryotes. The eight histone proteins are shown in green, and the DNA helix in blue and white. The canonical nucleosome core particle consists of 147...
Trifonov EN: Nucleosome repeat lengths and columnar chromatin structure. J Biomol Struct Dyn 2015:1-6. Based on the quantitative analysis of nucleosome repeat length (NRL) distributions, the author proposed a dominant role of columnar chromatin structure (Figure 2c) in all eukaryotes....
The structural organisation of chromatin in eukaryotes plays an important role in a number of biological processes. Our results provide a comprehensive insight into the nuclear topography of human peripheral blood granulocytes, mainly neutrophils. The nuclei of granulocytes are characterised by a segmented...
We have shown previously that several functionally linked genes, encoding proteins involved in chromatin-structure dynamics, which are conserved in S. pombe and other crown-group eukaryotes, have been lost as a group in S. cerevisiae [ 43].How...
The meaning of CHROMATIN is a complex chiefly of DNA and histone in eukaryotic cells that is usually dispersed in the interphase nucleus and condensed into chromosomes in mitosis and meiosis and in which the nucleosome makes up its repeating subunits. Ho
Chromatin is the genetic material of eukaryotes. The core of a genomic chromatin fiber is an array of nucleosomes. Chromatin condenses the chromosomal DNA molecule into a globular territory in the nucleus. At the same time, chromatin is the substrate for functional processes such as transcription...