which should contribute to their differential embryo developmental potential. We first compared the interaction heatmaps between SCNT and fertilization in early 2-cell embryos. There is more distinct interdomain regional separation in SCNT embryos than in fertilization...
We used the R package Signac21to investigate differences in chromatin accessibility between cell types. Cell types can be distinguished based on whether differentially accessible chromatin regions (DAR) are “open” or “closed” (Fig.2a, Supplementary Data2). We employed a log-fold-change threshol...
Activating mutations in the tyrosine kinase JAK2 cause myeloproliferative neoplasms, clonal blood stem cell disorders with a propensity for leukaemic transformation. LIF signalling through JAK-STAT enables ES cell self-renewal. Here we show that mouse ES cells carrying the human JAK2V617F mutation coul...
- 《Cell》 被引量: 1206发表: 2010年 Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells Summary Chromatin is important for the regulation of transcription and other functions, yet the diversity of chromatin composition and the distribution along chromosomes are...
Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes Traditionally, neuroscientists have defined the identity of neurons by the cells' location, morphology, connectivity and excitability. However, the direct relationship between these parameters and the molecu...
Dissection of the developmental trajectories and the transcriptional networks that underlie them could aid understanding of the function of the root apical meristem in both dicots and monocots. Here, we present a single-cell RNA (scRNA) sequencing and chromatin accessibility survey of rice radicles. ...
文献分享——Occupancy maps of 208 chromatin-associated proteins in one human cell type 文章概览 一种人类细胞类型中208个染色质相关蛋白质的占据图谱 image 期刊名:Nature 影响因子:42.778 发表日期:2020.7.29 下载地址:https://www.nature.com/articles/s41586-020-2023-4...
However, all chromatin-remodelling complex subfamilies contain an ATPase-translocase 'motor' that translocates DNA from a common location within the nucleosome. In this Review, we discuss (and illustrate with animations) an alternative, unifying mechanism of chromatin remodelling, which is based on ...
3DCoop is an approach for computational inference of cell type-specific TR cooperation in 3D chromatin (and 1D mode without 3D information), by incorporating 3D chromatin interactions (required for 3D mode) and TR footprinting. Chromatin loops detected by 3C-based technologies (Hi-C, PCHi-C, Ch...
Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening Jimin Tan, Nina Shenker-Tauris, Javier Rodriguez-Hernaez, Eric Wang, Theodore Sakellaropoulos, Francesco Boccalatte, Palaniraja Thandapani, Jane Skok, Iannis Aifantis, David Feny...