The up-to-date literature on the diagnosis, clinical behaviour, follow-up and treatment of this tumour is reviewed. Results and Conclusions: Laryngeal chondrosarcoma of the thyroid cartilage is a rare entity, especially in women. It is a slowly growing tumour easily confused with benign chondroma...
(Fig.4c) and associated to a concomitant up-regulation of major immune checkpoint such asPDL1(Fig.4d). These results suggest that this molecular definition of the most aggressive subtype of chondrosarcoma is defined by an immune-active microenvironment, as previously described for approximately half...
* Final gross prices may vary according to local VAT. Get Access Abstract.The incision often described in resection of the pubic bone is one that essentially traces the outline of this bone from the pubic tubercle along the superior pubic ramus, the pubic symphysis, and then the inferior pubic...
Chondrosarcomas are primary malignant bone tumors that have a poor prognosis. WNT1-inducible signaling pathway protein-3 (WISP-3, also termed CCN6) belongs to the CCN family of proteins and is implicated in the regulation of various cellular functions, s
At the 4-month follow-up, 67% of patients had observed disease control. Additionally, 7 of the 12 patients opted to continue on the study. The longest disease control duration observed for a patient in this cohort was approximately 8 months. In terms of safety, INBRX-109 demonstrated to be...
HOTAIR knockdown results in growth inhibition of human chondrosarcoma cells via miR-454-3p upregulation and Stat3 signaling inactivation in vivo. To further verify these in vitro findings, we used an in vivo xenograft model. HCS-2/8 cells stably infected with Lv-shHOTAIR or Lv- miR-454-3p...
* Final gross prices may vary according to local VAT. Get Access Abstract The foot is an uncommon location for chondrosarcoma. The presentation, diagnosis, pathological findings, surgical treatment and follow-up of three patients with chondrosarcoma in this rare location are presented. Though nons...
The up-to-date literature on the diagnosis, clinical behaviour, follow-up and treatment of this tumour is reviewed. Results and Conclusions: Laryngeal chondrosarcoma of the thyroid cartilage is a rare entity, especially in women. It is a slowly growing tumour easily confused with benign chondroma...
To date, no consistent genetic abnormality has been associated with chondrosarcoma. The tumors are heterogeneous and often have a number of abnormalities in gene expression. The following examples provide evidence of a novel gene, csa-1, that is expressed in a human chondrosarcoma cell line and in...
BACKGROUNDExperience in the treatment of laryngeal chondrosarcoma is based on about 250 cases reported to date. The standard therapy is conservative surgery. Radiotherapy has universally been regarded as ineffective in the treatment of this disease.METHODSA patient with a laryngeal chondrosarcoma was ...