Chondrosarcoma is highly malignant, with a strong capacity for local invasion as well as distant metastasis. Surgical resection remains the primary mode of therapy. This cancer shows a predilection for metastasis to the lungs. This article will highlight numerous molecular mechanisms mediating cell ...
Importantly, CCN6 knockdown profoundly inhibited chondrosarcoma cell metastasis to lung. Our findings reveal an important mechanism underlying CCN6-induced metastasis and they highlight the clinical significance between CCN6 and MMP-9 in regard to human chondrosarcoma. CCN6 appears to be a promising ...
Extraskeletal myxoid chondrosarcoma was diagnosed on the ventral abdomen of a kudu with metastasis to the omentum and lungs. Histopathological examination of the large (20 cm 脳 10 cm) primary, multinodular, moderately cellular neoplastic mass was characterised by neoplastic mesenchymal cells arranged ...
To test whether overexpression of CXCR4 drives chondrosarcoma cell metastasis, an in vitro cell invasion assay was performed. When cells were cultured in hypoxia and an SDF1 gradient, cell invasion increased 2 fold compared to normoxia, p < 0.05. Knockdown of Hif-1a or CXCR4 with specific siR...
It often tends to spread to the lungs, though it may spread to other locations as well. In general, patients will notice symptoms of the original tumor before any metastasis has taken place, giving them time to seek appropriate treatment. Assuming that the tumor can be removed without ...
Chest computed tomography demonstrated multiple lung micro-nodules suspect of metastasis. Laboratory testing of the anterior pituitary function revealed low free-T4 (11 pmol/l, n = 12-22) with normal TSH (0.4 mUI/l, n=0.3-4.2), low total testosterone (1.5 ugr/l, n = 3.3-8.1) with ...
Chondrosarcoma shows a predilection for metastasis to the lungs. IL-6 is a multifunctional cytokine that is associated with the disease status and outcomes of cancers. However, the effect of IL-6 on the migration activity of human chondrosarcoma cells is mostly unknown. Here, we found that IL-...
Chondrosarcoma shows a predilection for metastasis to the lungs. The stromal cell-derived factor 1 (SDF-1), constitutively secreted by human lung epithelium cells, has been shown to function in a key role for recruitment of neutrophils. Here, we found that human chondrosarcoma tissues and ...
It usually affects the axial skeleton, including the pelvis, scapula and base of the skull with frequent metastasis to the lungs. Primary pulmonary involvement with chondrosarcoma is rarely seen.#In this case report, we will discuss a case of endobronchial chondrosarcoma presenting as recurrent ...
Chondrosarcoma shows a predilection for metastasis to the lungs. WISP-1 is a cysteine-rich protein that belongs to the CCN (Cyr61, CTGF, Nov) family of matricellular proteins. However, the effect of WISP-1 on migration activity in human chondrosarcoma cells is mostly unknown. Here we found ...