Cardiac conduction abnormalities– anticholinesterases can slow the heart Peptic ulcer– Because of their pharmacological action, cholinesterase inhibitors may be expected to increase gastric acid secretion. Severe renal impairment– may require individual dose titration. Talk to your doctor if you are con...
cholinesterase inhibitors share a common biphasic effect on dopamine efflux: low (nanomolar) concentrations enhance release that is either electrically evoked or spontaneous, with maximal effects of 12–24%, while higher (micromolar) concentrations strongly attenuate release[174]. These in vitro effects ...
Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic syndrome of the central nervous system that causes a decline in cognitive function and language ability. Cholinergic deficiency is associated with AD, and various cholinesterase inhibitors have been developed ...
Considering the relatively high potency of PP compared to other extracts tested in similar assays (eel AChE), the active constituents must be potent inhibitors of the enzyme, possibly with IC50 in the submicromolar range. The Pao pereira fraction at pH 7 (PP) showed a dose-dependent reversal ...
This study aimed to investigate the feasibility of predicting the long–term effects of cholinesterase inhibitors (ChEI) with common clinical neuroimaging parameters of Alzheimer’s disease, including medial temporal lobe atrophy (MTA) and white matter hyperintensity (WMH). Method A cohort of 353 patie...
inhibitors provided a fit to the electron density maps, all of the inhibitors were assigned to the R-enantiomers, on the basis of a possible cation-πinteraction between the positively charged nitrogen of the piperidine moiety and the side chain of Tyr332, which is not possible for S-...
www.nature.com/scientificreports OPEN The anti‑Alzheimer potential of novel spiroindolin‑1,2‑diazepine derivatives as targeted cholinesterase inhibitors with modified substituents Hormoz Pourtaher 1, Alireza Hasaninejad 1*, Shahrokh Zare 2, Nader Tanideh 2 & Aida...
Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and α,β-unsaturated ketone group: Journal of Enzyme Inhibition and Medicinal Chemistry: Vol 0, No 0 ...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook The following article is fromThe Great Soviet Encyclopedia(1979). It might be outdated or ideologically biased. Anticholinesterase Agents a group of medicinal substances that slow the activity of cholinesterase (an...
On the basis of the similarity of the general structure concept of compounds 2–17 and some other MTDLs previously developed as MAO B inhibitors [41], we evaluated the biological activity of the target compounds toward human MAO B (hMAO B) enzyme. All compounds (2–17) were screened for...