The cholinergic system has long been known for its role in acquisition and retention of new information. Scopolamine, a muscarinic acetylcholine receptor antagonist impairs multiple memory systems, and this has promoted the notion that drug-induced side effects are responsible for diminished task ...
Effects of anti-cholinergic and cholinergic drugs on habituation to motion in rats. The effects of the anti-cholinergic drug scopolamine, an anti-motion sickness drug, and of the cholinergics physostigmine and neostigmine on habituation to... M Morita,N Takeda,S Hasegawa,... - Acta Oto-Laryngo...
showed an abolished response to PPN/LDT stimulation in the presence of cholinergic blockers (−7.2 ± 4.9%; 15 min after drug delivery; Fig.5c). The inhibition to the laser was partially recovered ~45 min after the drug application (−36.15 ± 16.37%). These results re...
Mediation of tick SG fluid secretion by cholinomimetic drug pilocarpine, has been considered as a common saliva induction process in many tick species worldwide14,33,34. Injection of the muscarinic acetylcholine receptor (mAChR) agonist, pilocarpine, into partially-fed hard tick females induces robus...
They are however especially useful in drug-induced parkinsonism (Chapter 11). The anticholinergic drugs used to treat drug-induced parkinsonism are tertiary amines (benztropine, trihexyphenidyl and procyclidine). Their extra-CNS antimuscarinic effects are much weaker than those of atropine. Diphenhydramine...
Irinotecan (CPT-11) is an anticancer drug that occasionally produces acute cholinergic side effects. Preliminary findings suggest that these are mediated t... HM Dodds,LP Rivory - 《Molecular Pharmacology》 被引量: 86发表: 1999年 Phase II randomised trial of raltitrexed–oxaliplatin vs raltitrexed...
药理学讲义06 Cholinergic Agonists Chapter6CholinergicAgonists 胆碱受体激动药和作用于胆碱酯酶药 CholinergicTransmissions varioussynapsesinthecentralnervoussystem autonomicganglia(ortho-andparasympathetic)andadrenalmedulla somaticneuromuscularjunction postganglionicparasympatheticfibers 2 DrugActions varioussynapsesinthecentral...
21. Galantamine is a cholinergic drug clinically approved for treating cognitive deterioration in patients with Alzheimer’s disease22,23. This cholinergic drug is well tolerated when the drug dose is gradually escalated22,23,24. The robust anti-inflammatory and beneficial metabolic activities of ...
(~ECl) in the presence of a drug cocktail containing 50 μM DL-AP4, 20 μM CNQX and 100 μM UBP-310, which block AMPA, NMDA and kainate-type glutamate receptors, as well as ON bipolar cell activity mediated by type 6 metabotropic glutamate receptors. Further pharmacological ...
These studies show that PPI incorporation of phosphate and inositol increases 50鈥 100 per cent in response to CARB within 5 min of drug and label administration. These responses were greater in the cerebral cortex and brainstem-midbrain regions than in the cerebellum, and they were blocked by ...