Choline metabolism in cancer: implications for diagnosis and therapy. Expert Rev Mol Diagn 2006;6: 821-9.Glunde K, Jacobs MA, Bhujwalla ZM. Choline metabolism in cancer: implications for diagnosis and therapy. Expert Review of Molecular Diagnostics. 2006; 6(6): 821-829....
Magnetic resonance studies from the last 10 years have conclusively demonstrated that choline metabolism is altered in a wide variety of cancers. In cancer, the choline metabolite profile is characterized by an elevation of phosphocholine and total choline-containing compounds. This elevation is increasin...
Choline metabolism is commonly deregulated in cancer, leading to increased levels of choline metabolites. This Review discusses the deregulation of choline metabolism in cancer, its reciprocal interaction with oncogenic signalling and the possible clinic
Recent characterization of abnormal phosphatidylcholine metabolism in tumor cells by nuclear magnetic resonance (NMR) has identified novel fingerprints of ... E Iorio,D Mezzanzanica,P Alberti,... - 《Cancer Research》 被引量: 498发表: 2005年 Choline metabolism in cancer: implications for diagnosis...
This elevation has been observed in almost every single cancer type studied with NMR spectroscopy and can be used as an endogenous biomarker of cancer. In this article, we have summarized some of the observations on the choline phospholipid metabolism of cancer cells and tumors, and make a case...
Choline metabolism closely involves in protecting the integrity of cell membrane, coordinating the methylation and synthesizing important neurotransmitters [11]. In cancer, the rapid proliferation of malignant tumor cells promotes a large amount of choline uptake through the overexpression of enzymes, ...
Radiomics offers little explainability. This study aims to develop a radiomics model (Rad-Score) using diffusion-weighted imaging (DWI) to predict high-risk patients for nodal metastasis or recurrence in endometrial cancer (EC) and corroborate with choli
Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivoGemcitabine diphosphate choline is a majo... - 《British Journal of Cancer》 被引量: 14发表: 2014年 Uptake and Utilization of Lyso-phosphatidylethanolamine by Saccharomyces cerevisiae...
inmammalian cellmembranes, and is critical in the transport of excesstriglyceridesfrom the liver. As a result,cholinedeficiency has been associated with the development ofhepatosteatosis, or fatty liver, and is the onlynutritional deficiencyfound to cause cancer in theabsenceof known carcinogens. One ...
Here we investigated the relationship between the aberrant choline metabolism observed in most cancers and PD-L1 expression in triple-negative human MDA-MB-231 breast cancer cells, and characterized the metabolic effects of PD-L1 downregulation. Methods: Experiments were performed with MDA-MB-231 ...