Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity. ERK8 is able to counteract, in immortalized human mammary cells, ERRα activation induced by the EGF receptor pathway, often deregulated in breas...
Tamoxifen (Tx) interacts with high affinity to the microsomal antiestrogen binding site (AEBS) which is a hetero-oligomeric complex involved in cholesterol... de Medina, Philippe,S Silvente-Poirot,M Poirot - 《Autophagy》 被引量: 161发表: ...
In primates, the CL also retains its ability to secrete estrogen throughout the luteal lifespan; some of the large/granulosa-lutein cells in the primate contain P450aromatase, thus indicating that the primate CL may retain the two cell-follicular model of estrogen biosynthesis during the luteal ...
The pathway for cholesterol biosynthesis. In cholesterol biosynthesis, all the carbon atoms are derived from acetyl-CoA. The biosynthesis of cholesterol can be divided into four stages. (I) Synthesis of mevalonate (MVA). Two molecules of acetyl-CoA are reversely catalyzed by thiolase to form aceto...
Reproductive hormones such as estrogen, progesterone, and testosterone are synthesized from a common cholesterol precursor pathway. We hypothesized that us... CNB Merz,MB Olson,BD Johnson,... - 《American Journal of Medicine》 被引量: 89发表: 2002年 Evaluation of lipid-lowering therapy and choles...
The oxysterol 27-hydroxycholesterol attenuates cancer cell growth through its ability to inhibit cholesterol uptake/synthesis Previously, we and others have shown that the oxysterol 27HC, produced from cholesterol by the monooxygenase CYP27A1, can function as a partial agonist of the estrogen receptor ...
Insight into the importance of estrogens in ovarian function in women comes from the study of subjects in whom estrogen synthesis is impaired. Only a few studies have been performed on women with 17α-hydroxylase/17,20 lyase deficiency who are incapable of producing thecal androgens to support gr...
There are three pathways that deliver cholesterol to arterial vessels and other peripheral cells—the lipid absorption pathway, the exogenous pathway (from the food intake of cholesterol) and the endogenous pathway where cholesterol is produced directly by the liver. All three pathways can result in ...
Cholesterol is a precursor of steroid hormones including the female hormones progesterone and estrogen. In breast cancer cholesterol abundance relates to cancer progression, invasion, and metastatic ability. Most steroid-receptor positive breast cancers respond well to the hormone targeting therapies during ...
to clinical treatments in use today. In this study, we demonstrated that cholesterol and mevalonate treatments were able to activate the estrogen-related receptor alpha (ERRα) pathway, increasing the expression levels of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α),...