Furthermore, we found that lipid-lowering drugs modify the association between plasma oxysterols levels and amyloid deposition in the brain, visualized using PET. Conclusions: There are important relationships between brain degeneration, cholesterol metabolism and dementia that need to be better understood...
Further research is warranted to establish optimal LDL cholesterol levels in the elderly.doi:10.1002/alz.044364Julia C KuszewskiJay Jay Thaung ZawRachel HX WongPeter RC HoweJohn Wiley & Sons, LtdAlzheimer's and Dementia
We are very interested in the idea that higher HDL ('good') cholesterol levels may help the brain more efficiently clear the toxic amyloid at an early stage," Reed said. "If those questions were understood we could begin to think about how to change cholesterol levels so as to prevent ...
Since 1935 (or earlier), it has been known that low levels of thyroid hormone, also known as hypothyroidism, causes blood levels of cholesterol to rise above normal.[33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][5...
Alterations in the neuronal cholesterol levels have been associated with aging, cognitive decline, neurodegenerative diseases, etc. Therefore, our findings are important for a deeper understanding of the relationship between the cholesterol level and dysfunctions of the brain at the molecular level.doi:...
which are prescribed to lower cholesterol levels, and are one of the most successful pharmaceuticals in history[3]. However, with over 20enzymesinvolved in the endogenous production of cholesterol, many more regulatory processes exist post-HMGCR than previously appreciated[4], making the pathway more...
the inhibition of endogenous cholesterol biosynthesis), can cross the blood–brain barrier and reduce cholesterol levels in the brain14. Niemann-Pick type C disease and Smith-Lemli-Opitz syndrome, both presenting cognitive impairments, are caused by alteration of cholesterol levels15,16. Interestingly,...
We investigated the alteration of brain cholesterol following chronic glutamate treatment. The alteration of cholesterol levels was evaluated in the hippocampus from the adult rats that received the subcutaneous injection with monosodium l-glutamate at 1, 3, 5, and 7 days of age. The regulation of...
while decreased levels may suggest a loss of metabolically active neurons and brain atrophy in Alzheimer's disease and multiple sclerosis.30–32 Recently, high serum levels of 24S-HC have also been seen acutely after NE.27 24S-HC further impacts cholesterol levels in the brain via reduced sterol...
Refined grains: grains that have been removed from the germ and bran (nutritive parts) and only maintain the endosperm. This type of food is characterized by having a high glycemic index, which causes peaks in blood glucose levels and causes an increase in insulin, a very negative effect in...