This might be explained with the light effect stimulating the sex steroid synthesis of the adrenal cortex which in turn could produce a sex steroid level exceeding that of the immature birds. None of the sex steroids alone causes an increase of the cholesterol level in the case of short day ...
Heart disease stubbornly remains one of the biggest killers in the UK, where there are7m peopleliving with the condition. During the past 60 years, the management of cholesterol has become an important weapon in the fight against this – and drugs called statins are often used in treatment. B...
Seasonal changes in plasma volume explained a substantial proportion of the observed variation. Overall, 22% more participants had total cholesterol levels of 240 mg/dL or greater (≥6.22 mmol/L) in the winter than in the summer. Conclusions This study confirms seasonal variation in blood lipid ...
Multiple linear regression showed that, together, these polymorphisms explain only 3.9% of the variation of HDL-C plasma levels. When significant two-way interactions between the polymorphisms were also taken into account, the explained variation rose to 12.5%. In a regression model that also ...
3a). This partial phenotype could be explained by the existence of 25 other SCL genes in the genome of C. elegans that could also be involved in cholesterol sequestration. In worms that do eventually exit the dauer state, growth is significantly delayed (Fig. 3b) and they reach fertility ...
Statins have become the miracle medicine of modern heart care, lowering cholesterol levels and and guarding against heart attacks in millions of Americans. In f
risk of coronary artery disease. It is not clear why some people should have high values and others very low. It appears that about half of the variation in HDL levels in the general population is explained bygeneticfactors. Fortunately not all individuals with low HDL levels get heart ...
The improving trend of cognition seen in soticlestat could be explained by other mechanisms such as modulation of the excitatory/inhibitory balance. One of the rationales for pharmacological activation of CH24H is acceleration of brain cholesterol turn-over, which is expected to be beneficial for ...
The total sterol level was reduced to about 76% relative to the control after 96 h of CLO treatment, which can be explained by the reduced supply of IPP due to inhibition of DXS activity (Figure 5C). Moreover, levels of carotenoids and chlorophylls also decreased (Figure 5C), further ...
5c), and could not be explained by transcriptional regulation of MARCHF6 and TRC8 (Supplementary Fig. 6a, b). Therefore, E3 ligase activity must be increased in hypoxia. Fig. 5: The hypoxia cholesterol response is mediated by MARCHF6 NADPH sensing. a SREBP2-Clover levels by flow cytometry...