By interacting with phospholipids and sphingolipids, cholesterol contributes to the characteristic physicochemical properties of membranes, mainly fluidity and passive permeability.140 Cholesterol is not homoge
of whether bilayer fluidity is important in modulating the function of membrane proteins under physiological conditions as is widely assumed, or whether the function of membrane proteins may be effectively buffered under normal operating conditions against changes in bilayer fluidity due to extraneous ...
It is necessary to ensure a proper membrane permeability and fluidity. It also serves as a precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D [1]. The chemical oxidation of cholesterol is a crucial reaction in the synthesis of many compounds that are of ...
Cholesterol serves as a precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D. It modulates membrane fluidity over the range of physiological temperatures. The hydroxyl group on cholesterol interacts with the polar head groups of the membrane phospholipids and sphingolipids, whi...
On the other hand, statins inhibit the pathway of dilichol, which plays a critical role in protein N-glycosilation and acts as a membrane anchor for the formation of a precursor oligosaccharide57. Therefore, the long-treatment with statins could lead to important impairment of intracellular ...
Cholesterol is a sterol lipid that plays important structural and functional roles in cellular membranous structures as it can provide rigidity to membrane fluidity. In addition, cholesterol and its metabolites, such as bile acids, oxysterols, certain vitamins, and steroid hormones, are essential for...
QtyAdd to Cart nt pyrene derivatives that contain a cholesterol moiety on one PEG terminus. Cholesterol is an essentail lipid component to build and maintain basic animal cell functional. It is one of animal cell-mmbrane structure components and establishes proper membrane permeability and fluidity....
Dynamin is a cellular GTPase which is essential for CCV formation and is required for membrane budding at a late stage during the transition from a fully formed pit to a pinched-off vesicle. Dynasore acts as a potent and specific inhibitor of dynamin by rapidly blocking coated vesicle formation...
Briefly, in the absence of PCSK9, hepatic LDLR is shuttled back to the plasma membrane after cholesterol delivery to the lysosome for degradation. PCSK9 binding, instead, prevents this LDLR shuttling and targets it for degradation. PCSK9 primarily acts on the LDLR as circulating plasma protein ...
N., 1973, Membrane fluidity, cholesterol and allosteric transitions of membrane-bound Mg2+ -ATPase, (Na+ - K+)-ATPase and acetylcholinesterase from rat erythrocytes, FEBS Lett. 38:101 .Bloj B, Morero RD, Farias RN (1973a) Membrane fluidity, cholesterol and allosteric transitions of membrane-...