n.Abbr.CCK A hormone produced principally by the small intestine in response to the presence of fats, causing contraction of the gallbladder, release of bile, and secretion of pancreatic digestive enzymes. Also calledpancreozymin. American Heritage® Dictionary of the English Language, Fifth Edit...
nouna gastrointestinal hormone that stimulates the secretion of pancreatic enzymes and the contraction and emptying of the gall bladder Related Words gastrointestinal hormone GI hormones Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc. ...
CCK (Cholecystokinin) Rodger A. Liddle, in Encyclopedia of Endocrine Diseases, 2003 Introduction Cholecystokinin (CCK) is a peptide hormone produced by endocrine cells of the upper small intestine. It is secreted on ingestion of a meal and is the major hormone responsible for pancreatic enzyme secr...
With CCK, the inhibition occurred mainly in the serotonergic system and in the Zucker strain, while new effects appeared in the dopaminergic system of lean rats of both strains. With bombesin, vagotomy inhibited the effects in the dopaminergic system in all lean rats, while new effects were ...
is found to be widely distributed in the brain7. An interesting function of CCK is the role it plays in stimulating the CCK receptor and subsequently regulating food consumption, which may prove to be a highly useful treatment for obesity14. Exogenous administration CCK has been widely studied16...
How does CCK cause obesity? Cholecystokinin (CCK)reduces food intake and modulates vagal afferent neurons' ability to respond to intake-related signals. Deficient CCK signaling is commonly observed in animal models of diet-induced obesity. Does CCK cross the blood brain barrier?
a potential therapy for asthma patients with obesity. CCKAR expression in ASM Fig. 1: ASM cells express CCKAR and contract in response to CCK agonist. We next validated the expression ofCCKARin ASM cells using qRT-PCR analysis. We found thatCCKARis highly expressed in ASM cells but is very...
In addition to regulating vagal afferent nerve discharge, CCK also controls the expression of receptors and peptide neurotransmitters by these neurons; these actions are potentiated by leptin and inhibited by ghrelin. The responses of vagal afferent neurons to CCK are attenuated in obesity. Studies of...
The Cpe(fat)/Cpe(fat) mouse phenotype obviously involves multiple endocrine defects, however, it is tempting to speculate that this severe CNS deficiency in CCK 8 may be related to the adult-onset obesity seen in this mutant mouse. 展开 ...
Jejunoileal bypass surgery for obesity increases the risk of gallstone formation, and, contrary to expectations, the incidence is greater in patients with a long as compared to a short ileum left in continuity. Impaired gallbladder motility due to reduced cholecystokinin (CCK) stimulation could be...