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The presenting signs and symptoms may vary, and depend on the stage of the disease. Distinctive features are persistent right upper quadrant pain, anorexia, weight loss, and palpable mass. More advanced disease may present with weight loss, hepatomegaly, and jaundice. In the setting of ...
Perihilar cholangiocarcinoma usually occurswithout obvious symptomsin early stage. It may progress to advanced stage when jaundice and fever arise with loss of weight, drooping spirits and poor appetite. Soperiodical physical examinationespecially for hi...
Indeed, periductal infiltrating type cholangiocarcinomas, especially in the early stage, may be difficult to differentiate from benign strictures.80,103,104 Lymphadenopathy compresses and displaces rather than invades the extrahepatic ducts. Benign strictures complicating cholecystectomy or distal gastric ...
Cholangiocarcinoma is usually clinically silent, and unfortunately symptoms such as jaundice, abdominal pain, and weight loss usually emerge at an advanced stage that is beyond surgical excision. Surprisingly, about 50% of patients with extrahepatic cholangiocarcinomas are American Joint Committee of ...
However, the 4 year survival of the R0 resection group was 100%. Conclusions: The present results show that the prognosis of CCA is very poor in North-east Thailand. Most CCA patients receive only treatment to alleviate symptoms due to their advanced stage of disease. Complete surgical ...
Unresectable CCA refers to CCA tumors that have grown into nearby structures, blood vessels, or organs to the extent that surgical removal is not viable, and it includes most stage III and IV cases. Criteria for unresectability include non-constructible main portal vein involvement, bilateral ...
The efficacy of Truseltiq was based on a single-arm Phase 2 study which included 108 patients with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with an FGFR2 fusion or rearrangement. Ninety-nine percent of patients had metastatic (Stage IV) disease at the time...
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AFAP1-AS1 significantly overexpressed in advanced stage CCA lesions (tumor-node-metastasis, TNM stage III) than that in low stage CCA lesions (TNM stage I–II).Matrix metalloproteinases(MMPs) are associated with human diseases, they facilitate tumormetastasisvia degrading theextracellular matrix. It ...